中国一出生队列研究中脐带血浆中全氟烷基物质和甲状腺激素浓度与产前暴露的关系。
Prenatal exposure to perfluoroalkyl substances and thyroid hormone concentrations in cord plasma in a Chinese birth cohort.
机构信息
Department of Social Medicine and Reproductive Epidemiology, National Health Commission Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, #779 Lao Hu Min Road, Shanghai, 200032, China.
National Management Office of Neonatal Screening Project for CHD, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
出版信息
Environ Health. 2020 Nov 26;19(1):127. doi: 10.1186/s12940-020-00679-7.
BACKGROUND
Evidence of associations between prenatal exposure to perfluoroalkyl substances (PFASs) and fetal thyroid hormones (THs) is controversial, and few studies have estimated the associations, while addressing the high correlations among multiple PFASs. We aimed to examine the associations between prenatal PFAS exposure and thyroid hormone concentrations in cord blood.
METHODS
A total of 300 mother-infant pairs from the Shanghai-Minhang Birth Cohort Study were included. We measured the concentrations of eight PFASs in maternal plasma samples collected at 12-16 gestational weeks, as well as those of total thyroxine (T4), free T4 (FT4), total triiodothyronine (T3), free T3 (FT3), and thyroid stimulating hormone (TSH) in cord plasma. We estimated the associations between maternal PFAS concentrations and TH concentrations using linear regression and Bayesian kernel machine regression (BKMR) models.
RESULTS
In BKMR models, higher PFAS mixture concentrations were associated with increased T3 concentrations, and there were suggestive associations with increased FT3 concentrations. For single-exposure effects in BKMR models, a change in PFDA, PFUdA, and PFOA concentrations from the 25th to 75th percentile was associated with a 0.04 (95%CrI: - 0.01, 0.09), 0.02 (95%CrI: - 0.03, 0.07), and 0.03 (95%CrI: - 0.001, 0.06) nmol/L increase in T3 concentrations, respectively. PFOA, PFNA, and PFDA were the predominant compounds in PFASs-FT3 associations, and the corresponding estimates were 0.11 (95% CrI: 0.02, 0.19), - 0.17 (95% CrI: - 0.28, - 0.07), and 0.12 (95% CrI: - 0.004, 0.24) pmol/L, respectively. A change in PFNA and PFOA concentrations from the 25th to 75th percentile was associated with a - 1.69 (95% CrI: - 2.98, - 0.41) μIU/mL decrease and a 1.51 (95% CrI: 0.48, 2.55) μIU/mL increase in TSH concentrations. The associations of PFOA and PFNA with T3/FT3 were more pronounced in boys, while those with TSH were more pronounced in girls.
CONCLUSION
Our results suggest that prenatal exposure to multiple PFASs was associated with thyroid hormones in cord blood. However, individual PFAS had varied effects-differing in magnitude and direction-on fetal thyroid hormones.
背景
关于产前暴露于全氟烷基物质（PFASs）与胎儿甲状腺激素（THs）之间的关联，目前仍存在争议，且鲜有研究在考虑到多种 PFASs 之间高度相关性的情况下对其进行评估。本研究旨在探讨产前 PFAS 暴露与脐血中甲状腺激素浓度之间的关系。
方法
本研究纳入了来自上海闵行出生队列研究的 300 对母婴。我们在孕 12-16 周时测量了母亲血浆样本中 8 种 PFASs 的浓度，以及脐血中总甲状腺素（T4）、游离甲状腺素（FT4）、总三碘甲状腺原氨酸（T3）、游离三碘甲状腺原氨酸（FT3）和促甲状腺激素（TSH）的浓度。我们使用线性回归和贝叶斯核机器回归（BKMR）模型来估计母体 PFAS 浓度与 TH 浓度之间的关联。
结果
在 BKMR 模型中，较高的 PFAS 混合物浓度与 T3 浓度升高有关，且与 FT3 浓度升高呈显著关联。在 BKMR 模型中，对于单一暴露效应，PFDA、PFUdA 和 PFOA 浓度从第 25 百分位数到第 75 百分位数的变化与 T3 浓度分别升高 0.04（95%CrI：-0.01，0.09）、0.02（95%CrI：-0.03，0.07）和 0.03（95%CrI：-0.001，0.06）nmol/L 相关。在 PFASs-FT3 关联中，PFOA、PFNA 和 PFDA 是主要的化合物，相应的估计值分别为 0.11（95%CrI：0.02，0.19）、-0.17（95%CrI：-0.28，-0.07）和 0.12（95%CrI：-0.004，0.24）pmol/L。PFNA 和 PFOA 浓度从第 25 百分位数到第 75 百分位数的变化与 TSH 浓度分别降低 1.69（95%CrI：-2.98，-0.41）μIU/mL 和升高 1.51（95%CrI：0.48，2.55）μIU/mL 相关。PFOA 和 PFNA 与 T3/FT3 的关联在男孩中更为明显，而与 TSH 的关联在女孩中更为明显。
结论
我们的研究结果表明，产前暴露于多种 PFASs 与脐血中的甲状腺激素有关。然而，单一 PFAS 对胎儿甲状腺激素的影响在大小和方向上存在差异。
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