Department of Medicine, Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
VA New England Healthcare System, Boston University School of Medicine, Boston, Massachusetts.
J Am Coll Cardiol. 2020 Nov 10;76(19):2252-2266. doi: 10.1016/j.jacc.2020.08.078.
Coronary heart disease is a chronic, systemic disease with a wide range of associated symptoms, clinical outcomes, and health care expenditure. Adverse events from coronary heart disease can be mitigated or avoided with lifestyle and risk factor modifications, and medical therapy. These measures are effective in slowing the progression of atherosclerotic disease and in reducing the risk of thrombosis in the setting of plaque disruptions. With increasing effectiveness of prevention and medical therapy, the role of coronary artery revascularization has decreased and is largely confined to subgroups of patients with unacceptable angina, severe left ventricular systolic dysfunction, or high-risk coronary anatomy. There is a compelling need to allocate resources appropriately to improve prevention. Herein, we review the scientific evidence in support of medical therapy and revascularization for the management of patients with stable coronary heart disease and discuss implications for the evaluation of patients with stable angina and public policy.
冠心病是一种慢性、全身性疾病,具有广泛的相关症状、临床结局和医疗支出。通过生活方式和危险因素的改变以及药物治疗,可以减轻或避免冠心病的不良事件。这些措施在减缓动脉粥样硬化疾病的进展和减少斑块破裂时血栓形成的风险方面是有效的。随着预防和药物治疗效果的提高,冠状动脉血运重建的作用已经降低,主要局限于心绞痛无法耐受、严重左心室收缩功能障碍或高危冠状动脉解剖的亚组患者。迫切需要合理分配资源以改善预防措施。本文回顾了支持药物治疗和血运重建用于稳定型冠心病患者管理的科学证据,并讨论了对稳定型心绞痛患者评估和公共政策的影响。
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