Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Center for Health Behavior and Health Education, Vanderbilt University Medical Center, Nashville, TN.
Diabetes Care. 2021 Jan;44(1):26-34. doi: 10.2337/dc20-0961. Epub 2020 Nov 5.
Text messaging interventions have high potential for scalability and for reductions in health disparities. However, more rigorous, long-term trials are needed. We examined the long-term efficacy and mechanisms of a tailored text messaging intervention.
Adults with type 2 diabetes participated in a parallel-groups, 15-month randomized controlled trial and were assigned to receive Rapid Education/Encouragement and Communications for Health (REACH) for 12 months or control. REACH included interactive texts and tailored texts addressing medication adherence and nontailored texts supporting other self-care behaviors. Outcomes included hemoglobin A (HbA), diabetes medication adherence, self-care, and self-efficacy.
Participants ( = 506) were approximately half racial/ethnic minorities, and half were underinsured, had annual household incomes <$35,000, and had a high school education or less; 11% were homeless. Average baseline HbA was 8.6% ± 1.8%; 70.0 ± 19.7 mmol/mol) with 219 having HbA ≥8.5% (69 mmol/mol). Half were prescribed insulin. Retention was over 90%. Median response rate to interactive texts was 91% (interquartile range 75%, 97%). The treatment effect on HbA at 6 months (-0.31%; 95% CI -0.61%, -0.02%) was greater among those with baseline HbA ≥8.5% (-0.74%; 95% CI -1.26%, -0.23%), and there was no evidence of effect modification by race/ethnicity or socioeconomic disadvantage. REACH improved medication adherence and diet through 12 months and self-efficacy through 6 months. Treatment effects were not significant for any outcome at 15 months. REACH reduced barriers to adherence, but barrier reduction did not mediate outcome improvements.
REACH engaged at-risk patients in diabetes self-management and improved short-term HbA. More than texts alone may be needed to sustain the effects.
短信干预措施具有很高的可扩展性和减少健康差距的潜力。然而,需要进行更严格、长期的试验。我们研究了定制短信干预的长期效果和机制。
患有 2 型糖尿病的成年人参加了一项平行组、15 个月的随机对照试验,并被分配接受 Rapid Education/Encouragement and Communications for Health(REACH)12 个月或对照组。REACH 包括针对药物依从性的互动短信和定制短信,以及支持其他自我护理行为的非定制短信。结果包括血红蛋白 A(HbA)、糖尿病药物依从性、自我护理和自我效能。
参与者(n=506)约一半为少数民族,一半为保险不足,年收入<$35,000,高中学历或以下,11%无家可归。平均基线 HbA 为 8.6%±1.8%(69 mmol/mol),219 人 HbA≥8.5%(69 mmol/mol)。一半人被开了胰岛素。保留率超过 90%。互动短信的中位回复率为 91%(四分位距 75%,97%)。治疗 6 个月时对 HbA 的影响(-0.31%;95%置信区间-0.61%,-0.02%)在基线 HbA≥8.5%的患者中更大(-0.74%;95%置信区间-1.26%,-0.23%),且种族/民族或社会经济劣势没有证据表明存在效应修饰。REACH 通过 12 个月改善了药物依从性和饮食,通过 6 个月改善了自我效能。治疗效果在 15 个月时对于任何结果都不显著。REACH 减少了药物依从性的障碍,但障碍减少并没有介导结果的改善。
REACH 使处于危险中的患者参与糖尿病自我管理,并改善了短期的 HbA。可能需要不仅仅是短信来维持效果。