Walczyk M H, McCarron D A
Department of Medicine, Oregon Health Sciences University, Portland 97201.
Compr Ther. 1987 Nov;13(11):10-6.
Although the complexities of cardiovascular physiology preclude any one factor from assuming the role of the key determinant of elevated blood pressure, the large body of evidence that is accumulating based on epidemiologic observation and studies in experimental and human hypertension support the contention that maintenance of normal calcium metabolism is associated with a lower arterial pressure. Dietary calcium supplementation in human essential hypertension appears to be an effective nonpharmacologic means of lowering blood pressure in some patients, especially those with evidence of a calcium-deficient state. In addition, preliminary evidence has raised questions as to whether a relationship exists between salt sensitivity and disordered calcium homeostasis in some hypertensive patients, and whether there is an important role for calcium in the regulation of other hormonal systems involved in blood pressure regulation.
尽管心血管生理学的复杂性使得任何一个因素都无法成为血压升高的关键决定因素，但基于流行病学观察以及实验性和人类高血压研究积累的大量证据支持了这样一种观点，即维持正常的钙代谢与较低的动脉血压相关。在人类原发性高血压中，补充膳食钙似乎是一些患者降低血压的一种有效的非药物手段，尤其是那些有钙缺乏状态证据的患者。此外，初步证据引发了一些问题，即在某些高血压患者中盐敏感性与钙稳态紊乱之间是否存在关联，以及钙在调节其他参与血压调节的激素系统中是否发挥重要作用。
