Kurtz T W, Morris R C
J Hypertens Suppl. 1986 Dec;4(5):S129-31.
To investigate whether provision of supplemental dietary calcium could attenuate hypertension in the deoxycorticosterone (DOC) model of hypertension we directly measured mean arterial pressure (MAP) in uninephrectomized rats given DOC, a fixed amount of dietary NaCl, and supplemental dietary calcium as CaCO3 or CaCl2. After 4 weeks MAP in rats given 4% dietary calcium as CaCO3 was significantly lower than the in controls given 0.5% calcium as CaCO3. Provision of 2% calcium as CaCO3, however, failed to attenuate hypertension. Provision of just 1% dietary calcium as CaCl2 attenuated hypertension without inducing impaired weight gain or hypophosphataemia. These findings demonstrate that in rats given DOC and NaCl, provision of supplemental dietary calcium can attenuate hypertension. The findings suggest that: (1) the blood pressure response to supplemental calcium can be determined by the anionic component of the calcium salt consumed, and (2) the antihypertensive effect of supplemental calcium is not just a consequence of impaired weight gain or hypophosphataemia.
为了研究补充膳食钙是否能减轻脱氧皮质酮（DOC）高血压模型中的高血压，我们直接测量了接受DOC、固定量膳食氯化钠以及作为碳酸钙或氯化钙的补充膳食钙的单侧肾切除大鼠的平均动脉压（MAP）。4周后，给予4%碳酸钙作为膳食钙的大鼠的MAP显著低于给予0.5%碳酸钙作为膳食钙的对照组。然而，给予2%碳酸钙作为膳食钙未能减轻高血压。仅给予1%氯化钙作为膳食钙可减轻高血压，且不会导致体重增加受损或低磷血症。这些发现表明，在给予DOC和氯化钠的大鼠中，补充膳食钙可减轻高血压。这些发现表明：（1）对补充钙的血压反应可由所摄入钙盐的阴离子成分决定，（2）补充钙的降压作用不仅仅是体重增加受损或低磷血症的结果。
