Gupta Rohit, Beg Saman, Jain Alok, Bhatnagar Shrish
Department of Gastroenterology, AIIMS, Rishikesh, Uttarakhand, India.
Department of Pediatrics, Era's Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India.
Indian J Med Microbiol. 2020 Jul-Dec;38(3 & 4):261-264. doi: 10.4103/ijmm.IJMM_20_331.
Although children with novel coronavirus infection (COVID-19) typically present with fever and respiratory symptoms, some children have reported gastrointestinal (GI) symptoms including vomiting and diarrhoea during the course of the disease. The continuous positive detection of the viral RNA from faeces in children even after nasopharyngeal swabs turned negative suggests that the GI tract may shed virus and a tentative faecal-oral transmission. The presence of angiotensin-converting enzyme 2 receptor and transmembrane serine protease 2, which are the key proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry process, in the GI tract can explain the digestive symptoms in COVID-19. COVID-19 has implications for the management of children with chronic luminal diseases. There is increasing concern regarding the risk that children with inflammatory bowel disease being infected with SARS-CoV-2.
尽管新型冠状病毒感染（COVID-19）患儿通常表现出发热和呼吸道症状，但有些患儿在病程中报告出现了胃肠道（GI）症状，包括呕吐和腹泻。即使鼻咽拭子检测结果转为阴性后，仍持续从儿童粪便中检测到病毒RNA，这表明胃肠道可能会排出病毒，并存在潜在的粪口传播途径。胃肠道中存在血管紧张素转换酶2受体和跨膜丝氨酸蛋白酶2，这两种是严重急性呼吸综合征冠状病毒2（SARS-CoV-2）进入细胞过程的关键蛋白，这可以解释COVID-19中的消化症状。COVID-19对慢性腔道疾病患儿的管理有影响。人们越来越担心炎症性肠病患儿感染SARS-CoV-2的风险。
