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利用亚细胞靶向提高癌症治疗效果的纳米医学精确设计策略。

Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting.

机构信息

Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.

School of Mechanical and Automotive Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, Shandong, China.

出版信息

Signal Transduct Target Ther. 2020 Nov 6;5(1):262. doi: 10.1038/s41392-020-00342-0.

DOI:10.1038/s41392-020-00342-0
PMID:33154350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7644763/
Abstract

Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets. The optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level, which play a key role in carcinogenesis. Therefore, to improve the therapeutic efficiency of drugs, researchers need to focus on delivering not only the therapeutic agents to the target tissues and cells but also the drugs to the relevant subcellular structures. In this review, we discuss the most recent construction strategies and release patterns of various cancer cell subcellular-targeting nanoformulations, aiming at providing guidance in the overall design of precise nanomedicine. Additionally, future challenges and potential perspectives are illustrated in the hope of enhancing anticancer efficacy and accelerating the translational progress of precise nanomedicine.

摘要

抗癌治疗的疗效在很大程度上取决于治疗剂到达其最终靶点的能力。大多数癌症治疗剂的最佳靶点通常是亚细胞水平的生物大分子，这些生物大分子在致癌作用中起着关键作用。因此，为了提高药物的治疗效率，研究人员需要专注于不仅将治疗剂递送到靶组织和细胞，而且还将药物递送到相关的亚细胞结构。在这篇综述中，我们讨论了各种癌细胞亚细胞靶向纳米制剂的最新构建策略和释放模式，旨在为精确纳米医学的整体设计提供指导。此外，还说明了未来的挑战和潜在的前景，以期提高抗癌疗效并加速精确纳米医学的转化进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ef/7644763/3a3b469035ea/41392_2020_342_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ef/7644763/2d5f037f0991/41392_2020_342_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ef/7644763/106e180427ab/41392_2020_342_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ef/7644763/2e6bcb66aff1/41392_2020_342_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ef/7644763/3a3b469035ea/41392_2020_342_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ef/7644763/2d5f037f0991/41392_2020_342_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ef/7644763/106e180427ab/41392_2020_342_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ef/7644763/2e6bcb66aff1/41392_2020_342_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8ef/7644763/3a3b469035ea/41392_2020_342_Fig4_HTML.jpg

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本文引用的文献

[1]
Controlled loading of albumin-drug conjugates ex vivo for enhanced drug delivery and antitumor efficacy.

J Control Release. 2020-12-10

[2]
Dually Enzyme- and Acid-Triggered Self-Immolative Ketal Glycoside Nanoparticles for Effective Cancer Prodrug Monotherapy.

Nano Lett. 2020-7-8

[3]
Versatile activatable vSIRPα-probe for cancer-targeted imaging and macrophage-mediated phagocytosis of cancer cells.

J Control Release. 2020-7-10

[4]
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.

Cell. 2020-4-16

[5]
Toward a More Precise Future for Oncology.

Cancer Cell. 2020-4-13

[6]
NIR light-activated dual-modality cancer therapy mediated by photochemical internalization of porous nanocarriers with tethered lipid bilayers.

J Mater Chem B. 2017-11-14

[7]
Enhanced nuclear delivery of anti-cancer drugs using micelles containing releasable membrane fusion peptide and nuclear-targeting retinoic acid.

J Mater Chem B. 2017-9-14

[8]
Photoactivatable Prodrug-Backboned Polymeric Nanoparticles for Efficient Light-Controlled Gene Delivery and Synergistic Treatment of Platinum-Resistant Ovarian Cancer.

Nano Lett. 2020-5-13

[9]
Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner.

ACS Nano. 2020-4-28

[10]
Catcher in the rel: Nanoparticles-antibody conjugate as NF-κB nuclear translocation blocker.

Biomaterials. 2020-7

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