Center for Pharmaceutical Engineering and Sciences, Department of Pharmaceutics, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23220, United States.
ARC Centre of Excellence for Nanoscale Biophotonics, Graduate School of Biomedical Engineering, University of New South Wales, Kensington 2052, NSW, Australia.
Prog Lipid Res. 2020 Jul;79:101052. doi: 10.1016/j.plipres.2020.101052. Epub 2020 Jul 15.
The emerging nanomedicine therapeutics have incorporated photonics technologies to develop precise medical treatment. Among the light regulated approaches, light-induced liposome technology has been explored and developed as a novel tool for spatiotemporal control of cargo release. Compared with the traditional liposome formulation, this triggering feature largely enhanced the therapeutic efficacy and minimized the side effects of the therapeutic substance. In this review paper, we discussed the basics of the light-induced liposomes including the engineering methods and photoresponsiveness mechanisms. We also reviewed current biomedical studies relating to light-induced liposome delivery systems, with an emphasis in the field of cancer therapy.
新兴的纳米医学治疗方法已经将光子学技术融入其中，以开发精确的医疗方法。在受光调控的方法中，光诱导脂质体技术已被探索和开发为一种用于货物释放时空控制的新型工具。与传统的脂质体配方相比，这种触发特性大大提高了治疗物质的疗效，同时最小化了其副作用。在这篇综述论文中，我们讨论了光诱导脂质体的基本原理，包括工程方法和光响应机制。我们还回顾了当前与光诱导脂质体递药系统相关的生物医学研究，重点关注癌症治疗领域。
