实用的早期癌症检测：区分癌前组织中稳定和不稳定的基因组。
Practical early cancer detection: distinguishing stable from unstable genomes in pre-cancerous tissues.
机构信息
Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge, Cambridge, UK.
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK.
出版信息
Br J Cancer. 2021 Feb;124(4):683-685. doi: 10.1038/s41416-020-01142-7. Epub 2020 Nov 6.
Abstract
Barrett's oesophagus has been known for many years to display early changes to the genome consistent with the risk for oesophageal adenocarcinoma. Recently we have shown that this information can be used without knowledge of individual gene mutations to accurately predict a patient's future risk of malignant progression.
摘要
巴雷特食管多年来一直被认为其基因组早期发生变化与食管腺癌风险相关。最近我们已经表明，即使不知道个体基因突变，也可以利用这些信息准确预测患者未来恶性进展的风险。
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