Haftu Hansa, Bitew Helen, Gebrekidan Atsede, Gebrearegay Hailemariam
Department of Pediatrics and Child Health, School of Medicine, College of Health Sciences, Mekelle University, Tigray, Ethiopia.
Department of Pharmacognosy, School of Pharmacy, College of Health Sciences, Mekelle University, Tigray, Ethiopia.
Patient Prefer Adherence. 2020 Oct 30;14:2085-2092. doi: 10.2147/PPA.S283011. eCollection 2020.
An umbilical granuloma is one of the common umbilical masses in young children which appears after the cords fall off, mainly due to an inflammatory reaction to subclinical infections. Though there are different recommendations of treatment modalities, which management modality is the best is not clear yet.
This systematic review aimed to assess the effectiveness of salt treatment in terms of complete resolution of the granuloma, any adverse effect, and any recurrence risk in those patients treated as inpatient or outpatient care.
The literature search was done using search engines including Google scholar, PubMed, and Medlin. Articles published since 1990 and written in the English language with a target population of young children (less than 24 months) were included. To retrieve the articles, umbilical granuloma, treatment of umbilical granuloma, salt treatment, and neonatal umbilical disorder were used as keywords.
This systematic review indicated that the majority of the studies done on salt treatment for umbilical granuloma show excellent response (complete resolution of the granuloma/discharge) with no adverse effect and no recurrence in the subsequent follow-up of the patients in almost all cases of the treatment group. Salt inside the occluded hyperosmolar chamber causes shrinkage of granuloma by a desiccant effect.
Cooking salt treatment for umbilical granuloma is effective, cheap, available, and easy to apply by non-health professionals. No side effects have been reported yet and a recurrence of the granuloma after treatment seems to be null.
脐肉芽肿是幼儿常见的脐部肿物之一，出现在脐带脱落后，主要是对亚临床感染的炎症反应。尽管有不同的治疗方式推荐，但哪种管理方式最佳尚不清楚。
本系统评价旨在评估盐疗法在肉芽肿完全消退、任何不良反应以及住院或门诊治疗患者的任何复发风险方面的有效性。
使用包括谷歌学术、PubMed和Medline在内的搜索引擎进行文献检索。纳入自1990年以来发表的、以幼儿（小于24个月）为目标人群、用英语撰写的文章。为检索文章，使用脐肉芽肿、脐肉芽肿的治疗、盐疗法和新生儿脐部疾病作为关键词。
本系统评价表明，大多数关于脐肉芽肿盐疗法的研究显示出极佳的反应（肉芽肿完全消退/分泌物消失），几乎所有治疗组患者在后续随访中均无不良反应且无复发。封闭的高渗腔内的盐通过干燥作用使肉芽肿缩小。
烹饪盐治疗脐肉芽肿有效、便宜、可获得且非卫生专业人员易于应用。尚未报告有副作用，治疗后肉芽肿复发似乎不存在。
