Srinivas Jois Ravisha, Rao Shripada
MBBS, FRACP MSc, Head of Neonatology, Joondalup Health Campus, WA; Associate Professor, Department of Health Sciences, Edith Cowan University, WA. Correspondence to:
MBBS, MD, DM, FRACP, Consultant Neonatologist, Perth Children's Hospital, WA; Associate Professor, University of Western Australia, WA.
Aust J Gen Pract. 2021 Aug;50(8):589-594. doi: 10.31128/AJGP-04-20-5371.
Umbilical granuloma is a common condition in infants. The aim of this study was to systematically review randomised controlled trials (RCTs) of topical treatment options for umbilical granuloma.
PubMed, Embase, Cochrane Library, Google Scholar and grey literature were searched in September 2020.
Eleven RCTs (n = 890) that studied the use of silver nitrate, topical steroids, ethanol wipes, electrocautery, cryocautery, copper sulphate and common salt were included. Common salt achieved resolution in >90% of cases in five studies and 54-80% in two studies. Topical steroids, silver nitrate, copper sulphate and cryocautery achieved resolution in >90% and ethanol wipes in 50-65% of cases. Local side effects reported with topical steroids, silver nitrate, cryocautery and electrocautery varied in each study. Salt application did not cause side effects. The risk of bias was high in many RCTs.
While the majority of the interventions were effective in treating umbilical granuloma, salt application appears to be simple and effective, with minimal complications.
脐肉芽肿是婴儿常见病症。本研究旨在系统评价治疗脐肉芽肿局部治疗方案的随机对照试验（RCT）。
于2020年9月检索了PubMed、Embase、Cochrane图书馆、谷歌学术和灰色文献。
纳入了11项研究硝酸银、局部类固醇、乙醇擦拭、电灼、冷冻、硫酸铜和食盐使用情况的随机对照试验（n = 890）。在五项研究中，食盐治疗使超过90%的病例症状消退，在两项研究中为54 - 80%。局部类固醇、硝酸银、硫酸铜和冷冻治疗使超过90%的病例症状消退，乙醇擦拭治疗使50 - 65%的病例症状消退。在每项研究中，局部类固醇、硝酸银、冷冻和电灼报告的局部副作用各不相同。使用食盐未引起副作用。许多随机对照试验存在高偏倚风险。
虽然大多数干预措施对治疗脐肉芽肿有效，但使用食盐似乎简单有效，并发症最少。
