心力衰竭患者中抗抑郁药的使用

The Use of Antidepressants in Patients with Heart Failure.

作者信息

Alsumih Norah, Alqahtani Rahaf, Almutairi Faisal, Faraj Rakan, Alsubeai Turki, Alghanim Ahmed, Alharbi Shmylan, Almodaimegh Hind

机构信息

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.

出版信息

J Saudi Heart Assoc. 2020 Apr 17;32(1):46-51. doi: 10.37616/2212-5043.1008. eCollection 2020.

DOI:10.37616/2212-5043.1008

PMID:33154891

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7640597/

Abstract

BACKGROUND

Heart failure (HF) is a chronic disease affecting patients' quality of life (QoL) and may cause depression. Recent studies reported that the prevalence of depression in patients with HF is 21.5%. Antidepressants, mainly selective serotonin reuptake inhibitors, are usually prescribed for HF patients diagnosed with depression. Some evidence supports antidepressant's role in improving symptoms by enhancing the psychological aspect of their QoL. Depression screening and treatment are important in the multidisciplinary management; however, their survival benefits are inconsistent. In our study, we aim to investigate the prevalence of depression and the use of antidepressants in patients with HF as well as to determine the acceptance of using antidepressants in such patients.

METHODS

This is a cross-sectional study conducted by interviewing HF outpatients at National Guard Hospital in Riyadh. Patients were assessed using Hamilton depression rating scale.

RESULTS

A total of 306 patients were included, with the majority (69%) being male and aged >61 years (60%). Patients' medical history was classified into different groups, with the largest proportion (39.9%) in the diabetic-hypertensive group, followed by a diabetic group (21.2%) and a hypertensive group (10.8%). Patients were classified according to the New York Heart Association Functional Classification, and most patients were in Class I (61.8%). Some of the patients (8.5%) had been diagnosed with depression. There was no statistically significant association between HF and depression ( > 0.05). However, 5.6% of patients had been prescribed antidepressants and 17.1% of patients believed that they required antidepressants. Moreover, there was a statically significant association between medical history and development of depression ( = 0.014).

CONCLUSIONS

The prevalence of depression in HF patients in our population was lower than reported. There was no association between HF stage, depression, and antidepressant use.

摘要

背景

心力衰竭（HF）是一种影响患者生活质量（QoL）的慢性疾病，可能导致抑郁。最近的研究报告称，HF患者中抑郁症的患病率为21.5%。抗抑郁药，主要是选择性5-羟色胺再摄取抑制剂，通常用于被诊断患有抑郁症的HF患者。一些证据支持抗抑郁药通过改善患者生活质量的心理方面来缓解症状。抑郁症的筛查和治疗在多学科管理中很重要；然而，它们对生存率的益处并不一致。在我们的研究中，我们旨在调查HF患者中抑郁症的患病率和抗抑郁药的使用情况，并确定此类患者对抗抑郁药的接受程度。

方法

这是一项横断面研究，通过对利雅得国民警卫队医院的HF门诊患者进行访谈来开展。使用汉密尔顿抑郁量表对患者进行评估。

结果

总共纳入了306名患者，其中大多数（69%）为男性，年龄>61岁（60%）。患者的病史分为不同组，糖尿病-高血压组占比最大（39.9%），其次是糖尿病组（21.2%）和高血压组（10.8%）。根据纽约心脏协会功能分级对患者进行分类，大多数患者为I级（61.8%）。一些患者（8.5%）被诊断患有抑郁症。HF与抑郁症之间无统计学显著关联（>0.05）。然而，5.6%的患者曾被开抗抑郁药，17.1%的患者认为自己需要抗抑郁药。此外，病史与抑郁症的发生之间存在统计学显著关联（=0.014）。