Zhengzhou People's Hospital, Zhengzhou, China.
Eur Rev Med Pharmacol Sci. 2020 Oct;24(20):10896-10901. doi: 10.26355/eurrev_202010_23454.
This study aims to discuss the unique clinical features of patients with 2019-nCoV in Zhengzhou City to provide references for clinical diagnosis and treatment.
Seventeen patients with 2019-nCoV in Zhengzhou People's Hospital from February to March 2020 were collected. Their epidemiology, clinical symptoms, laboratory examinations, and chest CT images were reviewed. All 17 patients were aged between 12-83 years, with an average age of 47 years, and consisted of 10 males (58.8%) and 7 females (41.2%). Two patients had histories of living or traveling in Wuhan, and 9 patients were attacked locally. The 6 remaining patients were unknown about incidence reasons.
The average incubation period was 10 days, and the average time of the course of the disease was 9 days. Among the participants, 12 patients had fever as the first symptoms and 5 patients had normal body temperature. One patient was symptom-free carrier, and one patient had serious symptoms. One patient developed from mild symptoms to severe symptoms, and 14 patients had mild symptoms. Moreover, 7 patients had complications of cardiovascular and cerebrovascular diseases and hypertension, 1 patient was in the advanced stage of squamous cell lung carcinoma, and 1 patient had diabetes mellitus, renal failure, and late-stage uremia. According to novel coronavirus nucleic acid test, 8 patients were positive, accounting for 47.1%. All patients were negative in the novel coronavirus IgM antibody test and negative in other common respiratory pathogen detection. All 17 patients had ground glass-like high-density shadow or stripped high-density shadow on lung CT images, accompanied with many affected lesions on two lungs. The average stay in hospital was 10 days, and the average time of the course of the disease was 9 days. After hospitalization, 15 patients were discharged from the hospital upon recovery, 1 patient was transferred to superior hospital for continuous treatment, and 1 patient died. Patients with 2019-nCoV in Zhengzhou People's Hospital were mainly attacked in local areas, and most of them had mild symptoms. The positive rate of the nucleic acid test was 47.1%.
The main clinical characteristics are increased neutrophil granulocytes, increased C-reactive proteins, decreased lymphocytes, ground glass-like or stripped lesions on lung CT image, common complications of cardiovascular and cerebrovascular diseases, and favorable prognosis.
探讨郑州市 2019 新型冠状病毒（2019-nCoV）感染患者的临床特点，为临床诊治提供参考。
收集 2020 年 2 月至 3 月郑州市人民医院收治的 17 例 2019-nCoV 感染患者的流行病学、临床症状、实验室检查和胸部 CT 影像等资料。所有患者年龄 12～83 岁，平均年龄 47 岁；男 10 例（58.8%），女 7 例（41.2%）；2 例有武汉居住史或旅行史，9 例本地发病，6 例发病原因不详。
潜伏期平均 10 天，发病至入院时间平均 9 天。首发症状以发热为主 12 例，体温正常 5 例。无症状感染者 1 例，重症患者 1 例。从轻症发展为重症 1 例，轻症 14 例。合并心血管、脑血管疾病及高血压者 7 例，晚期肺鳞癌 1 例，糖尿病、肾衰竭、尿毒症晚期 1 例。新型冠状病毒核酸检测 8 例阳性，占 47.1%；新型冠状病毒 IgM 抗体检测均为阴性，其他常见呼吸道病原体检测均为阴性。17 例患者胸部 CT 影像均表现为磨玻璃样高密度影或条索状高密度影，双肺多发病变，病变累及范围较广。住院时间平均 10 天，平均发病至出院时间 9 天。痊愈出院 15 例，转上级医院继续治疗 1 例，死亡 1 例。郑州市人民医院收治的 2019-nCoV 感染患者以本地发病为主，多为轻症，核酸检测阳性率为 47.1%。
郑州市人民医院 2019-nCoV 感染患者以本地发病为主，多为轻症，以发热、白细胞及中性粒细胞增高、淋巴细胞降低、胸部 CT 影像呈磨玻璃样或条索状病变为主要表现，合并常见的心脑血管疾病并发症，预后良好。
