Department for Blood-Borne Disease Testing, Blood Transfusion Institute of the Federation of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina.
Department of Medical Biochemistry, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Med Glas (Zenica). 2021 Feb 1;18(1):7-11. doi: 10.17392/1223-21.
Aim To present haemoglobin and ferritin parameters in donors to highlight the importance of serum ferritin testing for the purpose of evaluating iron depots in order to make recommendations for preserving a population of blood donors. Method A prospective study was conducted on 80 blood donors divided in two groups: group I (regular donors, n =40) and group II (irregular donors, n=40). Haemoglobin and ferritin were measured twice every 45 days, before two consecutive blood donations. Results By measuring haemoglobin and ferritin values before donation in both groups, a decrease of initial ferritin value in Group I relative to Group II was observed (without statistical significance). A significant decrease was found between repeated measurements for both parameters in both groups, indicating equal intensity of the decline in value regardless of a donor status. Measurement of ferritin before and after donation revealed statistically significant loss of ferritin in all examinees (p=0.011). The decline in haemoglobin after donation, although significant, did not fall below the reference value for donation in either women or men. Conclusion Results indicate the need for periodic monitoring of the plasma value of ferritin in voluntary donors who donate blood more than twice a year and the possible oral supplementation with iron.
介绍献血者的血红蛋白和铁蛋白参数，强调检测血清铁蛋白对于评估铁储存的重要性，以便为保存献血人群提出建议。
对 80 名献血者进行前瞻性研究，分为两组：组 I（定期献血者，n=40）和组 II（不定期献血者，n=40）。在两次连续献血前，每 45 天测量两次血红蛋白和铁蛋白。
通过测量两组献血前的血红蛋白和铁蛋白值，发现组 I 的初始铁蛋白值相对于组 II 下降（无统计学意义）。两组的两个参数在重复测量之间均发现显著下降，表明无论献血者的状态如何，铁蛋白值下降的强度相等。在所有受检者中，铁蛋白在献血前后的测量均显示出统计学显著的损失（p=0.011）。虽然血红蛋白在献血后的下降有显著意义，但女性和男性的血红蛋白值均未低于献血的参考值。
结果表明，对于每年献血超过两次的志愿献血者，需要定期监测血浆铁蛋白值，并可能口服补充铁。
