Bar-Ilan Institute for Nanotechnology and Advanced Materials, Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel.
ACS Appl Mater Interfaces. 2020 Nov 18;12(46):51940-51951. doi: 10.1021/acsami.0c14527. Epub 2020 Nov 6.
Fluorescent carbon dots (CDs) play a versatile role in materials science. Herein, we have developed alginate-derived nitrogen-doped CDs as a drug carrier and a toughening agent for hydrogels by a microwave-assisted method. In the first phase of work, we carried out covalent conjugation of the drug onto the CD surface for controlled delivery of drug molecules, and in the second phase of work, we demonstrated how CDs could act as a toughening agent as well as a viscosity modifier for poly(acrylic acid--methacrylamide) copolymer hydrogels. The hydrogels were evaluated by Fourier transformed infrared spectroscopy, X-ray photoelectron spectroscopy, and solid-state nuclear magnetic resonance. The hybrid hydrogels have been tested to be mechanically robust with extraordinary stretchability (∼1200% elongation at break), recoverable to the original position (low permanent set), tunable water uptake, and thixotropic character in dynamic stress. The crosslinked structure has been evaluated through void calculation revealing gradual densification of the network with increasing CD content. Exceptional gel strength (ratio of elastic modulus to loss modulus; '/″) has been achieved from analogous crosslinking made by CDs. The delayed network rupturing and superstretchability could make this material a good choice for soft biomaterials and soft robotics.
荧光碳点(CDs)在材料科学中具有多种用途。在此,我们通过微波辅助法开发了海藻酸钠衍生的氮掺杂 CDs 作为药物载体和水凝胶的增韧剂。在工作的第一阶段,我们将药物共价接枝到 CD 表面以控制药物分子的释放,在工作的第二阶段,我们证明了 CDs 如何既能作为增韧剂,又能作为聚(丙烯酸-丙烯酰胺)共聚物水凝胶的粘度改性剂。通过傅里叶变换红外光谱、X 射线光电子能谱和固态核磁共振对水凝胶进行了评估。混合水凝胶具有机械强度高、拉伸性好(断裂伸长率可达 1200%)、可恢复性好(低永久变形)、可调节吸水率和动态应力下的触变性等特点。通过空隙计算评估了交联结构,结果表明随着 CD 含量的增加,网络逐渐致密。与类似的 CD 交联相比,该材料具有优异的凝胶强度(弹性模量与损耗模量的比值;'/')。延迟的网络破裂和超拉伸性使这种材料成为软生物材料和软机器人的理想选择。
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