Cuellar O, Smart C
Transplantation. 1977 Aug;24(2):127-33. doi: 10.1097/00007890-197708000-00006.
Histoincompatibility was analyzed to describe as precisely as possible the sequence of gross morphological events taking place during allograft rejection among closely related conspecifics from a natural population of the bisexual lizard Cnemidophorus tigris. Two types of rejection were noted, depending on whether the grafts were sloughed or not. Abrupt rejection was typically characterized by hemorrhaging of the graft site, scale dissolution, and eventual sloughing of the graft. This process occurred in a graded sequence. Acute rejection occurred from 15 to 20 days, subacute from 30 to 45, and subchronic from 60 to 90. In the gradual form of rejection, the allografts were gradually replaced by host tissue during a period ranging from approximately 100 to 350 days post-transplantation. Such a gradation observed in both the abrupt and gradual categories suggests that large numbers of genes and/or alleles are responsible for the antigenic properties of skin in these lizards.
为了尽可能精确地描述来自双性蜥蜴丽斑麻蜥自然种群的亲缘关系密切的同种异体之间同种异体移植排斥过程中发生的大体形态学事件序列，对组织相容性进行了分析。根据移植物是否脱落，观察到两种类型的排斥反应。突然排斥的典型特征是移植部位出血、鳞片溶解以及移植物最终脱落。这个过程按分级序列发生。急性排斥发生在15至20天，亚急性排斥发生在30至45天，亚慢性排斥发生在60至90天。在逐渐排斥形式中，同种异体移植物在移植后约100至350天的时间段内逐渐被宿主组织替代。在突然和逐渐这两种类型中观察到的这种分级表明，大量基因和/或等位基因决定了这些蜥蜴皮肤的抗原特性。
