一种“糖衣”质子泵成为焦点：人 V-ATP 酶的高分辨率结构。
A "Sugar-Coated" Proton Pump Comes into Focus: High-Resolution Structure of a Human V-ATPase.
机构信息
SUNY Upstate Medical University, Department of Biochemistry and Molecular Biology, Syracuse, NY 13210, USA.
出版信息
Mol Cell. 2020 Nov 5;80(3):379-380. doi: 10.1016/j.molcel.2020.10.020.
PMID:33157012
Abstract
In this issue of Molecular Cell, Wang et al. (2020a) present near-atomic resolution cryoEM structures of a proton-pumping vacuolar ATPase from human cells, illuminating the glycosylation of integral subunits and identifying a novel and conserved glycolipid ligand.
摘要
在本期《分子细胞》中，Wang 等人（2020a）呈现了来自人细胞的质子泵液泡型 ATP 酶的近原子分辨率冷冻电镜结构，揭示了整合亚基的糖基化，并鉴定了一种新型且保守的糖脂配体。
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