Lv Tingting, Ye Mengfei, Luo Fangyi, Hu Baiqi, Wang Anzhe, Chen Jiaqi, Yan Junwei, He Ziyi, Chen Feng, Qian Chao, Zhang Jian, Liu Zheng, Ding Zhinan
Department of Behavioral Neurosciences, Science Research Center of Medical School, Shaoxing University, Shaoxing, Zhejiang, China.
Department of Psychiatry, Shaoxing Seventh People's Hospital, Shaoxing, Zhejiang, China.
Neurosci Biobehav Rev. 2021 Jan;120:159-172. doi: 10.1016/j.neubiorev.2020.10.027. Epub 2020 Nov 4.
The gut-brain axis has received considerable attention in recent years, and the "psychobiotics" concept indicates that probiotics have a potential positive effect on cognitive function. Therefore, the aim of this study was to quantitatively evaluate the influence of probiotics on cognition. We conducted a random-eff ;ects meta-analysis of 7 controlled clinical trials and 11 animals studies to evaluate the eff ;ects of probiotics on cognitive function. Probiotics supplementation enhanced cognitive function in both human (0.24 [0.05-0.42]; I = 0 %) and animal studies (0.90 [0.47-1.34]; I = 74 %). Subgroup analyses indicated that the effects of probiotics on cognitively impaired individuals (0.25 [0.05-0.45]; I = 0 %) were greater than those on healthy ones (0.15 [-0.30 to 0.60]; I = 0 %). Furthermore, compared with a multiple-probiotic supplement, a single strain of probiotics was more effective in humans. The meta-analysis provided some suggestions for probiotics intervention and tended to support a customized approach for different individuals to ameliorate cognitive disorders. Future additional clinical trials are necessary to evaluate therapeutic effect and influencing factors.
近年来，肠-脑轴受到了广泛关注，“精神益生菌”概念表明益生菌对认知功能具有潜在的积极影响。因此，本研究的目的是定量评估益生菌对认知的影响。我们对7项对照临床试验和11项动物研究进行了随机效应荟萃分析，以评估益生菌对认知功能的影响。补充益生菌在人体研究（0.24 [0.05 - 0.42]；I = 0%）和动物研究（0.90 [0.47 - 1.34]；I = 74%）中均增强了认知功能。亚组分析表明，益生菌对认知受损个体的影响（0.25 [0.05 - 0.45]；I = 0%）大于对健康个体的影响（0.15 [-0.30至0.60]；I = 0%）。此外，与多种益生菌补充剂相比，单一菌株的益生菌对人类更有效。荟萃分析为益生菌干预提供了一些建议，并倾向于支持针对不同个体改善认知障碍的定制方法。未来需要更多的临床试验来评估治疗效果和影响因素。
