从斯里兰卡榕树皮中活性导向分离抗炎成分。
Bioactivity-guided isolation of anti-inflammatory constituents from the bark of Streblus zeylanicus.
机构信息
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin 541004, China.
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin 541004, China.
出版信息
Fitoterapia. 2020 Nov;147:104770. doi: 10.1016/j.fitote.2020.104770. Epub 2020 Nov 4.
Based on anti-inflammatory activity to evaluate the effects to the release of NO, bio-assay guided separation of the bark of Streblus zeylanicus led to identify fifteen compounds, including four new terpenes (1, 2, 9, and 10), one new pentanoid glycoside (12), one new rumenic ester (13), together with nine known compounds (3-8, 11, 14, and 15). Their structures were elucidated using extensive NMR and HRESIMS spectroscopic data analyses. The stereochemistry of compound 10 was established by comparing the calculated and experimental ECD spectroscopic data. Compounds 1 and 2 showed moderate inhibition on nitric oxide (NO) production, with IC values of 10.21 μM and 15.53 μM, respectively.
基于抗炎活性评价对 NO 释放的影响，生物测定指导分离的思茅榕树皮导致鉴定出 15 种化合物，包括四种新萜类化合物（1、2、9 和 10）、一种新戊烷糖苷（12）、一种新的反式脂肪酸酯（13），以及 9 种已知化合物（3-8、11、14 和 15）。它们的结构是通过广泛的 NMR 和 HRESIMS 光谱数据分析来阐明的。化合物 10 的立体化学通过比较计算和实验的 ECD 光谱数据来确定。化合物 1 和 2 对一氧化氮（NO）的产生表现出中等抑制作用，IC 值分别为 10.21 μM 和 15.53 μM。
Zotero 插件