Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore, 138673, Singapore.
Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore, 138673, Singapore; Cardiovascular Metabolic Disorders Program, Duke-NUS Graduate School, Singapore; Institute of Medical Biology, A*STAR, Singapore.
Cancer Lett. 2021 Mar 1;500:263-270. doi: 10.1016/j.canlet.2020.10.038. Epub 2020 Nov 4.
Significant technological advances have enabled the discovery and identification of a new class of molecules, micropeptides or small ORF encoded peptides (SEPs) within non-coding RNAs (ncRNAs). As ncRNAs are well known to be transcriptionally silent, the discovery of SEPs implies that many ncRNAs are misannotated or play both coding and non-coding functions. SEPs have reportedly diverse regulatory roles in embryogenesis, myogenesis, inflammation, diseases, and cancer. SEPs appearing in different subcellular compartments show distinct functions. In this review, we summarized the functions of SEPs that have been characterized thus far. As SEPs are amenable to therapeutic development as biologics, understanding their underlying functions will provide novel targets for the treatment of inflammatory or metabolic disorders.
重大技术进步使人们能够在非编码 RNA（ncRNA）中发现和鉴定一类新的分子，即微肽或小开放阅读框编码肽（SEP）。由于 ncRNA 众所周知是转录沉默的，因此 SEP 的发现意味着许多 ncRNA 被错误注释或具有编码和非编码功能。据报道，SEP 在胚胎发生、肌发生、炎症、疾病和癌症中具有多种调节作用。出现在不同亚细胞区室的 SEP 显示出不同的功能。在这篇综述中，我们总结了迄今为止已经描述的 SEP 的功能。由于 SEP 可作为生物制剂进行治疗开发，因此了解其潜在功能将为治疗炎症或代谢紊乱提供新的靶标。
