Hao Lina, Hu Xibei, Zhu Bingqing, Li Wanhong, Huang Xiang, Kang Fang
Department of Anesthesiology, The First Affiliated Hospital of USTC (Anhui Provincial Hospital), Division of Life Sciences and Medicine, University of Science and Technology of China, 1st Swan lake road, Shushan District, Hefei, Anhui Province, China.
Medicine (Baltimore). 2020 Nov 6;99(45):e23061. doi: 10.1097/MD.0000000000023061.
This study is aims to compare the anesthetic safety of propofol combined with etomidate for painless gastroscopy.
Three hundred patients undergoing painless gastroscopy were randomly assigned to P, PE1, and PE2 groups. Patients were anesthetized with propofol (P group) or propofol combined with etomidate (volume ratio 1: 1, PE1 group; volume ratio 2: 1, PE2 group). The hemodynamics and adverse reactions were observed. The sleep quality satisfaction and nature of dreams were recorded.
Compared with pre-anesthesia, the mean arterial pressure and heart rate of the 3 groups were significantly slower during the examination and at the end of the examination. PE1 group had a higher incidence of muscle spasm, body moving, choking, and deglutition. The incidence of hypoxemia and injection pain was higher in P group. P and PE2 group had higher sleep quality satisfaction and dream incidence after awaking. However, there was no difference in the nature of dreams among 3 groups.
Our data indicate that the combination of 10 ml 1.0% propofol and 5 ml 0.2% etomidate for painless gastroscopy reduces adverse reactions while not affecting the patients respiratory function. Moreover, it is safe and effective, which is worthy of clinical application and promotion.
本研究旨在比较丙泊酚联合依托咪酯用于无痛胃镜检查的麻醉安全性。
将300例行无痛胃镜检查的患者随机分为P组、PE1组和PE2组。分别采用丙泊酚麻醉（P组）或丙泊酚联合依托咪酯麻醉（体积比1:1，PE1组；体积比2:1，PE2组）。观察血流动力学及不良反应。记录睡眠质量满意度及梦境情况。
与麻醉前比较，3组患者检查中及检查结束时平均动脉压和心率均明显减慢。PE1组肌肉痉挛、体动、呛咳及吞咽发生率较高。P组低氧血症及注射痛发生率较高。P组和PE2组苏醒后睡眠质量满意度及梦境发生率较高。但3组间梦境情况无差异。
我们的数据表明，10 ml 1.0%丙泊酚与5 ml 0.2%依托咪酯联合用于无痛胃镜检查可减少不良反应，同时不影响患者呼吸功能。此外，其安全有效，值得临床应用与推广。
