Department of Operating Room, The Third Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, China.
Medicine (Baltimore). 2023 Jan 6;102(1):e32612. doi: 10.1097/MD.0000000000032612.
Etomidate is often combined in rapid succession during induction of anesthesia. However, the effect of pretreatment with oxycodone on recovery of cognitive function and adverse effects has rarely been studied. We conducted a prospective randomized controlled trial to compare etomidate alone with etomidate combined with oxycodone in elderly patients undergoing painless gastroscopy.
Hundred elderly patients undergoing painless gastroscopy were divided into a control and an observation group, with 50 cases in each group. The age, gender, height, weight, body mass index and American Society of Anesthesiologists physical status (I/II) of patients in both groups were recorded. The recovery of cognitive function was compared in both groups using the Neurobehavioral Cognitive Status Examination. Adverse events, including somatic motor reactions, hypotension, bradycardia, myocardial tremor, nausea and vomiting, and injection pain, were also recorded in both groups. Moreover, heart rate, peripheral capillary oxygen saturation, systolic blood pressure, and diastolic blood pressure were evaluated in the 2 groups at different time points.
A total of 100 patients were enrolled in this study. The demographic characteristics in the 2 groups were not significantly different (P > .05). Regarding the recovery of cognitive functions, more subjects in the observation group passed the memory, arithmetic and orientation test than in the control group (P < .05). Fewer adverse events such as dynamic body reactions, cardiac tremor, nausea and vomiting, and injection pain occurred in the observation group than in the control group (P < .05). During anesthesia and after awakening, the results of peripheral capillary oxygen saturation, systolic blood pressure and diastolic blood pressure were better in the observation group than in the control group (P < .05).
Etomidate in combination with oxycodone for painless gastroscopic operation in the elderly is a safe and effective anesthetic strategy.
依托咪酯在麻醉诱导时经常连续快速给药。然而，奥沙可丁预处理对认知功能恢复和不良反应的影响很少被研究。我们进行了一项前瞻性随机对照试验，比较了单独使用依托咪酯与依托咪酯联合奥沙可丁在接受无痛胃镜检查的老年患者中的效果。
将 100 例接受无痛胃镜检查的老年患者分为对照组和观察组，每组 50 例。记录两组患者的年龄、性别、身高、体重、体重指数和美国麻醉医师协会身体状况（I/II）。采用神经行为认知状态检查比较两组患者认知功能的恢复情况。记录两组患者的不良反应，包括躯体运动反应、低血压、心动过缓、心肌震颤、恶心呕吐和注射疼痛。此外，评估两组患者在不同时间点的心率、外周毛细血管血氧饱和度、收缩压和舒张压。
本研究共纳入 100 例患者。两组患者的人口统计学特征无显著差异（P>0.05）。在认知功能恢复方面，观察组通过记忆、算术和定向测试的患者多于对照组（P<0.05）。观察组发生躯体运动反应、心肌震颤、恶心呕吐和注射疼痛等不良反应的患者少于对照组（P<0.05）。麻醉期间和苏醒后，观察组患者的外周毛细血管血氧饱和度、收缩压和舒张压结果均优于对照组（P<0.05）。
依托咪酯联合奥沙可丁用于老年无痛胃镜检查是一种安全有效的麻醉策略。
