Xie Donghua, Xiang Yueyun, Wang Aihua, Xiong Lili, Kong Fanjuan, Liu Zhiyu, Wang Hua
Department of Information Management.
NHC Key Laboratory of Birth Defect for Research and Prevention (Hunan Provincial Maternal and Child Health Care Hospital), 58 Xiangchun Road, Changsha, Hunan, China.
Medicine (Baltimore). 2020 Nov 6;99(45):e23094. doi: 10.1097/MD.0000000000023094.
To identify the prevalence of chronic disease and behavior risk factors of adverse pregnancy outcome for pre-pregnancy couples in Hunan province, China.A retrospective study including cross-sectional datas from the Free Pre-pregnancy Health Check (FPHC) surveillance system of Hunan, China in 2019 was conducted. Microsoft Excel 2010 was used for preliminary data analysis. The fowllowing descriptive analysis, t-tests, and Chi-Squared tests were carried out using SPSS 25.0.Among 419,971 couples, 182,450 (21.72%) individuals were older than 35 years, 257,471(69.48%) couples planned to have a second or additional child and 114,892 (27.36%) individuals had a history of adverse pregnancy outcomes. The mean number of risk factors of adverse pregnancy outcome was higher in males than that in females (2.17 per male vs 1.92 per female). The prevalence/proportions of hypertension, increased psychological pressure, high alanine transaminase or creatinine, smoking, passive smoke exposure, alcohol use, and exposure to environmental risk factors were higher in males than that in females (2.43% vs 1.35%, 0.68% vs 0.54%, 12.80% vs 5.93%, 2.52% vs 1.47%, 27.70% vs 0.24%, 10.94% vs 3.58%, 15.62% vs 1.07%, and 1.46% vs 1.15%, respectively). The proportion of females with an abnormal cervix was 3.35%, and the proportion of males with abnormal wrapping was 1.90%. The prevalence/proportions of anemia and work-related pressure or social tensions were higher in females than that in males (5.53% vs 0.51%, 15.39% vs 13.61%, and 8.22% vs 7.88%, respectively).History of adverse pregnancy outcomes and age olderthan 35 years were important risk factors for pre-pregnancy couples in Hunan province. The mean number of risk factors was higher in males than that in females. Hypertension, increased psychological pressure, high alanine transaminase and creatinine levels, smoking, passive smoke exposure, alcohol use, and exposure to dangerous environmental factors were the major risk factors for males. Anemia, work-related pressure and social tensions were the major risk factors for females.
为确定中国湖南省孕前夫妇慢性病患病率及不良妊娠结局的行为危险因素。开展了一项回顾性研究，纳入了2019年中国湖南省免费孕前健康检查（FPHC）监测系统的横断面数据。使用Microsoft Excel 2010进行初步数据分析。使用SPSS 25.0进行以下描述性分析、t检验和卡方检验。
在419,971对夫妇中，182,450名（21.72%）个体年龄超过35岁，257,471对（69.48%）夫妇计划生育二孩或更多子女，114,892名（27.36%）个体有不良妊娠结局史。男性不良妊娠结局危险因素的平均数量高于女性（男性为2.17个/人，女性为1.92个/人）。男性高血压、心理压力增加、丙氨酸转氨酶或肌酐升高、吸烟、被动吸烟、饮酒以及暴露于环境危险因素的患病率/比例高于女性（分别为2.43%对1.35%、0.68%对0.54%、12.80%对5.93%、2.52%对1.47%、27.70%对0.24%、10.94%对3.58%、15.62%对1.07%以及1.46%对1.15%）。宫颈异常的女性比例为3.35%，包皮异常的男性比例为1.90%。女性贫血、工作相关压力或社会紧张的患病率/比例高于男性（分别为5.53%对0.51%、15.39%对13.61%以及8.22%对7.88%）。
不良妊娠结局史和年龄超过35岁是湖南省孕前夫妇的重要危险因素。男性危险因素的平均数量高于女性。高血压、心理压力增加、丙氨酸转氨酶和肌酐水平升高、吸烟、被动吸烟、饮酒以及暴露于危险环境因素是男性的主要危险因素。贫血、工作相关压力和社会紧张是女性的主要危险因素。
