Chen Yong, Wu Fangfang, Zhang Li, Du Li, Yan Xiang
The First Hospital of Lanzhou University.
Evidence-Based Nursing Center, School of Nursing, Lanzhou University.
Medicine (Baltimore). 2020 Nov 6;99(45):e23120. doi: 10.1097/MD.0000000000023120.
Meprin is a member of the astaxanthin family; it performs many functions through a wide range of proteolytic enzyme activities during health and disease, including tumors and inflammatory conditions. The purpose of this systematic review was to evaluate the predictive value of MEP1A in tumor prognosis.
A comprehensive search was conducted on PubMed, Cochrane library, and Web of Science Database using a developed search strategy. The Newcastle-Ottawa Scale (NOS) or the Cochrane Collaboration's tool for assessing risk of bias will be used to access the methodological quality of included studies, and GRADE will be applied to evaluate evidence quality of outcomes. All analyses were performed by Stata 15.0.
The results will systematically summarize and display the currently collected evidence on the predictive value of MEP1A in different tumor prognosis.
This study may play a certain role in predicting the prognosis of cancer patients in the future, and may prompt clinicians to make necessary treatment or prevention plans as soon as possible.
It is not necessary because the present systematic review is based on published studies.
INPLASY2020100005.
甲素是虾青素家族的一员；在健康和疾病（包括肿瘤和炎症状态）期间，它通过广泛的蛋白水解酶活性发挥多种功能。本系统评价的目的是评估MEP1A在肿瘤预后中的预测价值。
使用制定的检索策略在PubMed、Cochrane图书馆和科学网数据库进行全面检索。将使用纽卡斯尔-渥太华量表（NOS）或Cochrane协作网评估偏倚风险的工具来评估纳入研究的方法学质量，并应用GRADE来评估结局的证据质量。所有分析均使用Stata 15.0进行。
结果将系统地总结并展示目前收集到的关于MEP1A在不同肿瘤预后中预测价值的证据。
本研究可能在未来预测癌症患者的预后方面发挥一定作用，并可能促使临床医生尽快制定必要的治疗或预防计划。
不需要，因为本系统评价基于已发表的研究。
INPLASY注册号：INPLASY2020100005。
