Department of Community Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
School of Public Health, Florida International University, Miami, FL 33199, USA.
Int J Environ Res Public Health. 2020 Nov 4;17(21):8140. doi: 10.3390/ijerph17218140.
Insulin resistance is a risk factor for various diseases. Chronic organophosphate exposure has been reported to be a cause of insulin resistance in animal models. This cross-sectional study aimed to evaluate the association between organophosphate exposure and insulin resistance in pesticide sprayers and nonfarmworkers. Participants aged 40-60 years, consisting of 150 pesticide sprayers and 150 nonfarmworkers, were interviewed and assessed for their homeostatic model assessment of insulin resistance (HOMA-IR) level. Organophosphate (OP) exposure was measured in 37 sprayers and 46 nonfarmworkers by first morning urinary dialkyl phosphate (DAP) metabolites. The DAP metabolite levels were not different in either group except for diethylthiophosphate (DETP; = 0.03), which was higher in sprayers. No significant association was observed between DAP metabolite levels and HOMA-IR. Wearing a mask while handling pesticides was associated with lower dimethyl metabolites (95% CI = -11.10, -0.17). Work practices of reading pesticide labels (95% CI = -81.47, -14.99) and washing hands after mixing pesticide (95% CI = -39.97, -3.35) correlated with lower diethyl alkylphosphate level. Overall, we did not observe any association between OP exposure and insulin resistance in pesticide sprayers and the general population. However, personal protective equipment (PPE) utilization and work practice were associated with OP exposure level in sprayers.
胰岛素抵抗是多种疾病的危险因素。有报道称，慢性有机磷暴露是动物模型中胰岛素抵抗的一个原因。本横断面研究旨在评估农药喷洒者和非农业工人中有机磷暴露与胰岛素抵抗之间的关系。研究对象为年龄在 40-60 岁的参与者，包括 150 名农药喷洒者和 150 名非农业工人，对他们进行了问卷调查，并评估了他们的稳态模型评估的胰岛素抵抗（HOMA-IR）水平。通过对 37 名喷洒者和 46 名非农业工人的晨尿中二烷基磷酸（DAP）代谢物测量了有机磷（OP）暴露情况。除了二乙基硫代磷酸酯（DETP； = 0.03），两组的 DAP 代谢物水平没有差异，而 DETP 在喷洒者中更高。DAP 代谢物水平与 HOMA-IR 之间没有观察到显著相关性。在处理农药时戴口罩与较低的二甲基代谢物有关（95%CI=-11.10，-0.17）。阅读农药标签（95%CI=-81.47，-14.99）和混合农药后洗手（95%CI=-39.97，-3.35）等工作实践与较低的二乙基烷基磷酸酯水平相关。总的来说，我们没有观察到农药喷洒者和普通人群中 OP 暴露与胰岛素抵抗之间存在任何关联。然而，个人防护设备（PPE）的使用和工作实践与喷洒者中的 OP 暴露水平有关。
