Medical Information Center, Kyushu University Hospital, Fukuoka 812-8582, Japan.
Int J Environ Res Public Health. 2020 Nov 4;17(21):8159. doi: 10.3390/ijerph17218159.
Studies of biomarkers of lifestyle-related diseases in Japanese cohorts are scarce. This study aimed to analyze trends in risk markers of lifestyle-related diseases using age-period-cohort (APC) analysis. Data on systolic blood pressure and BMI from 1973 to 2018 and serum glucose, triglyceride, and high-density lipoprotein cholesterol levels from 1989 to 2018 available from the National Health and Nutrition Survey were used. Values for each of the risk markers for each age, period, and cohort were estimated using APC analysis. For women, a decrease in all the risk markers of lifestyle-related diseases was observed in individuals born between the 1930s and approximately 1970. Therefore, female individuals born in approximately 1970 were considered to have the lowest risk of developing lifestyle-related and cardiovascular diseases. Meanwhile, the cohort effect on all the risk markers deteriorated for the younger cohorts, and changes in lifestyle behavior are needed for cohorts born more recently. For men, the trends in risk markers across the cohorts differed, and the relative risk of lifestyle-related diseases for each cohort differed according to disease. These results could help understand cohort-specific risks for lifestyle-related disease and enable identification of high-risk populations who could benefit from preventive measures.
关于日本队列中与生活方式相关疾病的生物标志物的研究很少。本研究旨在通过年龄-时期-队列（APC）分析来分析与生活方式相关疾病的风险标志物的趋势。使用了来自国家健康和营养调查的 1973 年至 2018 年的收缩压和 BMI 数据，以及 1989 年至 2018 年的血清葡萄糖、甘油三酯和高密度脂蛋白胆固醇水平。使用 APC 分析估计了每个年龄、时期和队列的每个风险标志物的值。对于女性，在 20 世纪 30 年代至 1970 年左右出生的人群中，所有与生活方式相关疾病的风险标志物均呈下降趋势。因此，大约 1970 年出生的女性被认为患与生活方式相关和心血管疾病的风险最低。同时，年轻队列的所有风险标志物的队列效应都恶化了，最近出生的队列需要改变生活方式行为。对于男性，各队列的风险标志物趋势不同，每个队列的与生活方式相关疾病的相对风险也因疾病而异。这些结果有助于了解特定队列的与生活方式相关疾病风险，并确定可以从预防措施中受益的高危人群。
