Division of Neonatology, Children's Hospital of Philadelphia/University of Pennsylvania, United States; Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, United States.
Larner College of Medicine at the University of Vermont, United States; Vermont Oxford Network, United States.
Semin Perinatol. 2020 Dec;44(8):151329. doi: 10.1016/j.semperi.2020.151329. Epub 2020 Oct 13.
Responsible use of antibiotics is critical to preserve their effectiveness and to minimize adverse outcomes associated with overuse and misuse. Newborn infants are a unique population with high rates of antibiotic exposure. In order to improve neonatal antibiotic use, accurate and meaningful metrics are required. In this review, we highlight and compare existing antibiotic use metrics in detail, including definitions, current applications, advantages, and limitations of each metric, with a focus on applicability to neonatal populations. We explore future directions for identification of accurate and meaningful metrics that will allow hospitals and stakeholders to pinpoint antibiotic utilization practices that should be emulated or avoided, and ultimately improve the safety and quality of neonatal care.
合理使用抗生素对于保持其有效性以及最大限度减少过度使用和滥用相关的不良后果至关重要。新生儿是一个抗生素暴露率很高的特殊群体。为了改善新生儿抗生素的使用情况，需要准确且有意义的衡量标准。在这篇综述中，我们详细地强调和比较了现有的抗生素使用衡量标准，包括每个标准的定义、当前应用、优点和局限性，重点是其在新生儿人群中的适用性。我们探讨了确定准确且有意义的衡量标准的未来方向，这些标准将使医院和利益相关者能够确定应该效仿或避免的抗生素使用实践，最终提高新生儿护理的安全性和质量。
