Defer G, Guezennec C Y, Fraitag B, Lhoste F
Département de Pharmacologie Clinique, Hôpital Henri-Mondor, Créteil, France.
Fundam Clin Pharmacol. 1987;1(2):135-43. doi: 10.1111/j.1472-8206.1987.tb00552.x.
Blood pressure, heart rate, oxygen consumption, plasma concentrations of catecholamines, renin, aldosterone and lactate were measured in 6 normotensive volunteers during a randomized cross-over study of oral ketanserin (20 mg X 7) and placebo; measurements were made at rest and during maximal dynamic exercise on a bicycle ergometer. At rest ketanserin reduced blood pressure without modifying heart rate or plasma noradrenaline and adrenaline. Duration of exercise and blood lactate levels did not differ between the ketanserin and the control group. During exercise only systolic blood pressure was significantly decreased on ketanserin at maximal work rate whereas heart rate did not change. Plasma noradrenaline was significantly increased and plasma aldosterone significantly decreased during exercise in ketanserin-treated subjects whereas plasma renin activity and plasma adrenaline remained unchanged. Finally, under ketanserin oxygen consumption during exercise was reduced. The results suggest that ketanserin might interfere with the sympathetic nervous system and aldosterone secretion in man.
在一项口服酮色林（20毫克×7）和安慰剂的随机交叉研究中，对6名血压正常的志愿者测量了血压、心率、耗氧量、血浆儿茶酚胺、肾素、醛固酮和乳酸的浓度；测量在静息状态下以及在自行车测力计上进行最大动态运动期间进行。静息时，酮色林降低了血压，但未改变心率或血浆去甲肾上腺素和肾上腺素。酮色林组和对照组之间的运动持续时间和血乳酸水平没有差异。运动期间，仅在最大工作率时，酮色林使收缩压显著降低，而心率未改变。在接受酮色林治疗的受试者运动期间，血浆去甲肾上腺素显著增加，血浆醛固酮显著降低，而血浆肾素活性和血浆肾上腺素保持不变。最后，在酮色林作用下，运动期间的耗氧量减少。结果表明，酮色林可能会干扰人体的交感神经系统和醛固酮分泌。
