Defer G, Guezennec Y C, Lhoste F
Eur J Clin Pharmacol. 1986;30(6):727-9. doi: 10.1007/BF00608224.
Blood pressure, heart rate, and plasma catecholamine concentrations were measured in 9 normotensive volunteers during a randomized cross-over study of oral nifedipine (10 mg X 5) and placebo; measurements were made at rest and during maximal anaerobic exercise. At rest nifedipine reduced blood pressure and increased heart rate and plasma noradrenaline, whereas plasma adrenaline did not change. During exercise, the blood pressure response was similar in nifedipine and placebo treated subjects; however, heart rate was significantly higher with nifedipine. Plasma noradrenaline increased more during exercise in nifedipine-treated subjects. By contrast, nifedipine inhibited the increase in plasma adrenaline induced by exercise. The results suggest that peripheral vasodilatation induced by nifedipine is responsible for increased sympathetic nerve activity, both at rest and during exercise, and that nifedipine inhibits adrenaline secretion in man.
在一项口服硝苯地平（10毫克×5）和安慰剂的随机交叉研究中，对9名血压正常的志愿者测量了血压、心率和血浆儿茶酚胺浓度；在静息状态和最大无氧运动期间进行测量。静息时，硝苯地平降低血压，增加心率和血浆去甲肾上腺素，而血浆肾上腺素未发生变化。运动期间，硝苯地平治疗组和安慰剂治疗组的血压反应相似；然而，硝苯地平组的心率显著更高。硝苯地平治疗组运动期间血浆去甲肾上腺素增加更多。相比之下，硝苯地平抑制运动诱导的血浆肾上腺素增加。结果表明，硝苯地平诱导的外周血管舒张是静息和运动期间交感神经活动增加的原因，且硝苯地平抑制人体肾上腺素分泌。
