Chatterjee S N
Transplant Proc. 1977 Sep;9(3):1579-82.
Use of metabolic inhibitors has been proven useful in hypothermic anoxic storage. The data are sparse about its effects in machine preservation when the hypothermic organ is oxygenated and metabolizing, although at a slow rate. Concentration of a particular drug is also important. They can, in fact, be injurious at wrong concentrations. Various drugs have been proven to be beneficial in protecting kidneys from ischemic injury. At present, methylprednisolone seems to be the best agent, offering a predictable and complete protection, thereby justifying its use in all donors where there is reasonable suspicion of warm ischemic damage.
代谢抑制剂已被证实在低温缺氧保存中有用。关于其在低温器官充氧并代谢（尽管速率缓慢）时对机器保存的影响的数据很少。特定药物的浓度也很重要。事实上，浓度不当可能会造成损害。各种药物已被证实在保护肾脏免受缺血性损伤方面有益。目前，甲基强的松龙似乎是最佳药物，能提供可预测的完全保护，因此在所有合理怀疑存在热缺血损伤的供体中使用是合理的。
