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[采用低温储存和机械延长灌注保存缺血性损伤的肾脏]

[Preservation of kidneys with ischemic injury using hypothermic storage and mechanical prolonged perfusion].

作者信息

Wienand P, Grundmann R, Bischoff A, Pichlmaier H

出版信息

Chir Forum Exp Klin Forsch. 1978(1978):275-80.

PMID:378605
Abstract

Dog kidneys were flushed and stored in Collins (n = 30) and Sacks (n = 32) solution under hypothermia. These results were compared with those gained by mechanical perfusion (n = 21). Before preservation, the kidneys were subjected to 15 - 60 min of warm ischemia then stored for 12 - 24 h. It was concluded that 12-h preservation time after 15-min ischemic injury was the limit of hypothermic storage preservation. Sacks' solution gave better results than Collins' solution as regards the immediate function after transplantation. In contrast, mechanical perfusion was well tolerated for 24-h preservation time after a warm ischemia of 30 min. In case of warm ischemic damage, mechanical perfusion should be preferred to hypothermic storage.

摘要

将犬肾在低温下用柯林斯溶液(n = 30)和萨克斯溶液(n = 32)进行冲洗并保存。将这些结果与通过机械灌注获得的结果(n = 21)进行比较。在保存前,肾脏经历15 - 60分钟的热缺血,然后保存12 - 24小时。得出的结论是,15分钟缺血性损伤后12小时的保存时间是低温储存保存的极限。就移植后的即刻功能而言,萨克斯溶液比柯林斯溶液效果更好。相比之下,在30分钟热缺血后,机械灌注在24小时的保存时间内耐受性良好。在热缺血损伤的情况下,应优先选择机械灌注而非低温储存。

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