Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, ROC.
Fujian Key Laboratory of Novel Functional Textile Fibers and Materials, Minjiang University, Fuzhou, China.
J Mater Sci Mater Med. 2020 Nov 7;31(11):107. doi: 10.1007/s10856-020-06411-8.
This study aims to construct tissue engineering stents by using the long fiber-reinforced thermoplastic (LFT) technique to develop artery stents. The experimental method combines fibers, the LFT technique, and electrospinning technique. First, the biodegradable polyvinyl alcohol yarns are twisted and coated in polycaprolactone/polyethylene glycol blends through the LFT technique. Next, the weft-knitting and heat treatment are used to establish the stent structure, after which poly(ethylene oxide) (PEO) is electrospun to coat the stents. The morphology, mechanical, and biological properties of tissue engineering stents are evaluated. The test results indicated that the use of the LFT technique retains the softness of filaments, which facilitates the subsequent weft-knitting process. The coating of blends and electrospinning of PEO have a positive influence on the tissue engineering stents, as demonstrated by the tensile strength of 59.93 N and compressive strength of 6.10 N. Moreover, the in vitro degradation of stents exhibits a stabilized process. The water contact angle is 20.33°, and the cell survival rate in 24 h is over 80%. The proposed tissue engineering stents are good candidates for artery stent structure.
本研究旨在利用长纤维增强热塑性（LFT）技术构建组织工程支架，开发动脉支架。实验方法结合纤维、LFT 技术和静电纺丝技术。首先，将可生物降解的聚乙烯醇纱线通过 LFT 技术捻合并涂覆在聚己内酯/聚乙二醇共混物中。然后，采用纬编织造和热处理来建立支架结构，之后对支架进行聚氧化乙烯（PEO）的静电纺丝涂层。评估了组织工程支架的形态、力学和生物学性能。测试结果表明，LFT 技术的使用保留了纤维的柔软性，从而便于后续的纬编织造过程。共混物的涂层和 PEO 的静电纺丝对组织工程支架有积极的影响，表现为拉伸强度为 59.93N 和压缩强度为 6.10N。此外，支架的体外降解呈现稳定的过程。水接触角为 20.33°，24 小时内细胞存活率超过 80%。所提出的组织工程支架是动脉支架结构的良好候选材料。
