Laboratory of Fiber Application and Manufacturing, Department of Fiber and Composite Materials, Feng Chia University, Taichung City 40724, Taiwan.
School of Textiles, Tianjin Polytechnic University, Tianjin 300387, China; Department of Chemical Engineering and Materials, Ocean College, Minjiang University, Fujian 350108, China; Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan; College of Textile and Clothing, Qingdao University, Shangdong 266071, China.
Mater Sci Eng C Mater Biol Appl. 2018 Oct 1;91:404-413. doi: 10.1016/j.msec.2018.05.030. Epub 2018 May 11.
This study proposes structural models of biodegradable vascular stents. One, two, or three plies of biodegradable polyvinyl alcohol (PVA) yarns are combined and twisted with twist factors of 2, 3, 4, 5, and 6 to form one-, two-, and three-ply PVA twisted yarns. The braided, warp-knitted, and weft-knitted PVA vascular stents are composed of PVA twisted yarns by using a braider, a warp knitting machine, and a weft knitting machine. The formation and mechanical properties of PVA vascular stents are evaluated, and the biological properties are examined in terms of biocompatibility through in vitro assay and subcutaneous embedding using in vivo assay. Test results indicate that the compression strength of PVA vascular stents is improved when using PVA twisted yarns containing a high number of plies and twist factor. Specifically, weft-knitted PVA vascular stents exhibit the optimal compression strength. PVA vascular stents treated with chemical cross-linking show weight loss lower than 3% after immersion in PBS solution for 30 days. Moreover, the antibacterial test and cell culture results suggest that PVA vascular stents are nontoxic and biocompatible. Subcutaneous embedding results show that PVA vascular stents retain intact formation when subcutaneously embedded in vivo for 28 days, indicating their good biological property. PVA vascular stents are suitable candidates for tissue engineering applications.
本研究提出了可生物降解血管支架的结构模型。将一层、两层或三层可生物降解的聚乙烯醇（PVA）纱线组合并以 2、3、4、5 和 6 的扭捻系数进行扭捻，形成一层、两层和三层 PVA 扭捻纱线。采用编织机、经编机和纬编机将编织、经编和纬编的 PVA 血管支架由 PVA 扭捻纱线构成。评估 PVA 血管支架的形成和力学性能，并通过体外试验和体内皮下埋植试验从生物相容性方面考察其生物性能。试验结果表明，采用多层层数和高扭捻系数的 PVA 扭捻纱线可以提高 PVA 血管支架的压缩强度。具体而言，纬编 PVA 血管支架表现出最佳的压缩强度。经化学交联处理的 PVA 血管支架在 PBS 溶液中浸泡 30 天后的失重率低于 3%。此外，抗菌试验和细胞培养结果表明，PVA 血管支架无毒性且具有生物相容性。皮下埋植试验结果表明，PVA 血管支架在体内皮下埋植 28 天后仍保持完整形态，表明其具有良好的生物性能。PVA 血管支架是组织工程应用的合适候选材料。
