Department of Nephrology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, China.
Renal Division, Department of Medicine, Peking University First Hospital, China; Institute of Nephrology, Peking University, China; Key Laboratory of Renal Disease, Ministry of Health of China, China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing, 100034, China.
Clin Nutr. 2021 Apr;40(4):2394-2400. doi: 10.1016/j.clnu.2020.10.036. Epub 2020 Oct 23.
Observational studies on dietary or circulating magnesium and risk of cardiovascular disease (CVD) in Chronic Kidney Disease (CKD) stage 1-4 have reported no-to-modest inverse associations. 24 h Urinary magnesium concentration (24 h UMg), an indicator of intestinal magnesium absorption, may provide better insight into the connection of CKD progression. We examined 3179 participants aged 18-74 years with CKD stage 1-4 in the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) study, a prospective population-based cohort study. Data were analysed using Spearman rank-order correlation coefficients for all comparisons. We also performed a time-to-event analysis of the data using the Kaplan-Meier survival model, Cox proportional hazard model and competing risk Fine and Gray subdistribution hazard model. During a median follow-up of 4.19 years (interquartile range, 3.43-5.09 years), when modelling end-stage renal disease (ESRD), CVD and death, 24 h UMg was associated with risk of CVD (HR, 1.612 (95% CI, 1.056-2.460)), while no significant association with ESRD and death endpoints could be detected. 24 h UMg risk variants display a modest association with CVD in CKD stage 1-4 patients. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT03041987. Registered January 1, 2012. (retrospectively registered) (https://www.clinicaltrials.gov/ct2/show/NCT03041987?term=Chinese+Cohort+Study+of+Chronic+Kidney+Disease+%28C-STRIDE%29&rank=1).
观察性研究表明，饮食或循环镁与慢性肾脏病（CKD）1-4 期心血管疾病（CVD）的风险呈负相关，但关联程度较弱。24 小时尿镁浓度（24 h UMg）是肠道镁吸收的一个指标，可能更能深入了解 CKD 进展的关系。我们在中国慢性肾脏病队列研究（C-STRIDE）中检查了 3179 名年龄在 18-74 岁的 CKD 1-4 期患者，这是一项前瞻性的基于人群的队列研究。使用 Spearman 秩相关系数对所有比较进行数据分析。我们还使用 Kaplan-Meier 生存模型、Cox 比例风险模型和竞争风险 Fine 和 Gray 亚分布风险模型对数据进行时间事件分析。在中位随访时间为 4.19 年（四分位距，3.43-5.09 年）期间，当对终末期肾病（ESRD）、CVD 和死亡进行建模时，24 h UMg 与 CVD 风险相关（HR，1.612（95%CI，1.056-2.460）），而与 ESRD 和死亡终点无显著关联。24 h UMg 风险变异与 CKD 1-4 期患者的 CVD 有一定关联。试验注册：ClinicalTrials.gov 标识符 NCT03041987。2012 年 1 月 1 日注册。（回顾性注册）（https://www.clinicaltrials.gov/ct2/show/NCT03041987？term=Chinese+Cohort+Study+of+Chronic+Kidney+Disease+%28C-STRIDE%29&rank=1）。
