Phothong Weeranut, Manuskiatti Woraphong, Cembrano Kathryn Anne G, Wanitphakdeedecha Rungsima, Bowornsathitchai Nutthamon
Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkok, 10700, Thailand.
Lasers Surg Med. 2021 Jul;53(5):616-621. doi: 10.1002/lsm.23342. Epub 2020 Nov 8.
Enlarged pores are one of the most common causes of skin surface irregularities. Existing studies supporting the benefit of lasers and energy-based devices (EBD) for this condition are limited, with a short duration of follow-up period. We aimed to evaluate the efficacy and adverse effects of Er:YAG laser for treatment of enlarged pores in dark-skinned patients.
STUDY DESIGN/MATERIALS AND METHODS: Nineteen subjects (aged 26-47 years) with skin phototypes III (21.1%) and IV (78.9%) and enlarged pores were treated with 4 monthly sessions of Erbium:YAG laser. Objective (ultraviolet light A video camera) and subjective (clinical evaluation by two blinded dermatologists) assessments were obtained at baseline, 1-month after each treatment and at 1, 3, and 6 months after the final treatment.
The weighted mean score of quartile grading scales showed significant improvement in pore size from baseline starting at 1-month after the third treatment and continued until 3 months after the fourth (final) treatment (P < 0.001). However, the improvement dropped significantly at 6 months after the final treatment. Objective measurements of the improvements in skin surface smoothness and wrinkles corresponded with the physician raters' clinical evaluation.
Erbium:YAG laser is a safe and effective treatment for enlarged pores in dark-skinned individuals. Maintenance treatments are recommended to achieve a longer-lasting outcome. Lasers Surg. Med. © 2020 Wiley Periodicals LLC.
毛孔粗大是皮肤表面不平整最常见的原因之一。目前支持激光和基于能量的设备（EBD）治疗这种情况的研究有限，随访期较短。我们旨在评估铒激光治疗深色皮肤患者毛孔粗大的疗效和不良反应。
研究设计/材料与方法：19名年龄在26 - 47岁之间、皮肤光型为III型（21.1%）和IV型（78.9%）且毛孔粗大的受试者接受了每月1次、共进行4次的铒激光治疗。在基线、每次治疗后1个月以及最后一次治疗后1、3和6个月进行客观（紫外线A摄像机）和主观（由两名不知情的皮肤科医生进行临床评估）评估。
四分位数分级量表的加权平均分显示，从第三次治疗后1个月开始，毛孔大小较基线有显著改善，并持续到第四次（最后一次）治疗后3个月（P < 0.001）。然而，在最后一次治疗后6个月，改善情况显著下降。皮肤表面光滑度和皱纹改善的客观测量结果与医生评估者的临床评价一致。
铒激光治疗深色皮肤个体的毛孔粗大是一种安全有效的方法。建议进行维持治疗以获得更持久的效果。激光外科医学。© 2020威利期刊有限责任公司。
