Mohamadi Farid, Pourgholi Elnaz, Vahabi Seyed Mohammad, Hosseini Fatemeh, Mahmoudi Hamidreza, Ehsani Amirhooshang, Etesami Ifa
Department of Dermatology, Razi Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
Lasers Med Sci. 2025 Jun 20;40(1):291. doi: 10.1007/s10103-025-04540-6.
Perioral aging manifests as fine lines, wrinkles, and structural changes, often requiring specialized treatment. Although laser systems are widely used in facial rejuvenation, few studies directly compare their efficacy in perioral rejuvenation. This study evaluates and compares the efficacy and safety of two laser systems-Erbium: glass laser and Nd: YAG combined with Er: YAG laser-for perioral rejuvenation. A prospective, comparative clinical trial was conducted with 36 female patients who sought perioral rejuvenation at a tertiary dermatology hospital. Participants were randomly assigned to either the erbium: glass group or the Nd: YAG combined with Er: YAG group, each receiving three treatment sessions at 4-week intervals. Efficacy was assessed through clinical wrinkle severity ratings, VisioFace imaging, and patient satisfaction scores. Safety was evaluated by monitoring adverse events. The mean ages in the erbium: glass and Nd: YAG combined with Er: YAG laser groups were 49.78 ± 6.59 and 46.72 ± 6.36 years, respectively, without significant difference (p > 0.05). All participants had Fitzpatrick skin types III- IV. Both treatment groups demonstrated significant improvements in supralabial lines and skin hyperpigmentation (p < 0.05). While erbium: glass was more effective in reducing supralabial lines, the difference between the two laser systems was not statistically significant. Conversely, improvement in corner lip wrinkles was statistically significant only in the Nd: YAG combined with Er: YAG laser group (p < 0.05). Erbium: glass showed significantly superior results in reducing pore count (p < 0.05). No significant difference was observed between the groups in terms of skin hyperpigmentation improvement. Both erbium: glass and Nd: YAG combined with Er: YAG laser are effective and safe options for perioral rejuvenation. Erbium: glass may be particularly suited for targeting superficial lines and pores, while Nd: YAG combined with Er: YAG laser appears more effective for treating deeper wrinkles. These findings support an individualized laser treatment selection approach based on specific skin concerns. Further studies with larger sample sizes and extended follow-up periods are recommended to confirm and expand on these results.
口周衰老表现为细纹、皱纹和结构变化，通常需要进行专门治疗。尽管激光系统在面部年轻化中广泛应用，但很少有研究直接比较它们对口周年轻化的疗效。本研究评估并比较了两种激光系统——铒玻璃激光和掺钕钇铝石榴石激光联合掺铒钇铝石榴石激光——对口周年轻化的疗效和安全性。在一家三级皮肤病医院对36名寻求口周年轻化的女性患者进行了一项前瞻性、对比临床试验。参与者被随机分配到铒玻璃组或掺钕钇铝石榴石激光联合掺铒钇铝石榴石激光组，每组每隔4周接受3次治疗。通过临床皱纹严重程度评分、VisioFace成像和患者满意度评分评估疗效。通过监测不良事件评估安全性。铒玻璃组和掺钕钇铝石榴石激光联合掺铒钇铝石榴石激光组的平均年龄分别为49.78±6.59岁和46.72±6.36岁，无显著差异（p>0.05）。所有参与者的皮肤类型均为菲茨帕特里克III-IV型。两个治疗组在上唇纹和皮肤色素沉着方面均有显著改善（p<0.05）。虽然铒玻璃激光在减少上唇纹方面更有效，但两种激光系统之间的差异无统计学意义。相反，仅在掺钕钇铝石榴石激光联合掺铒钇铝石榴石激光组中，唇角皱纹的改善具有统计学意义（p<0.05）。铒玻璃激光在减少毛孔数量方面显示出显著更优的效果（p<0.05）。两组在皮肤色素沉着改善方面未观察到显著差异。铒玻璃激光和掺钕钇铝石榴石激光联合掺铒钇铝石榴石激光都是口周年轻化有效且安全的选择。铒玻璃激光可能特别适合针对浅表纹路和毛孔，而掺钕钇铝石榴石激光联合掺铒钇铝石榴石激光似乎在治疗更深的皱纹方面更有效。这些发现支持基于特定皮肤问题的个体化激光治疗选择方法。建议进行更大样本量和更长随访期的进一步研究以证实并扩展这些结果。
