Department of Internal Medicine, Hebei Medical University, Shijiazhuang, 050017, Hebei, China.
Department of Endocrinology and Metabolic Diseases, Hebei General Hospital, Shijiazhuang, 050051, Hebei, China.
Lipids Health Dis. 2020 Nov 8;19(1):236. doi: 10.1186/s12944-020-01403-7.
Recent studies have suggested the triglyceride-glucose index (TyG index) may serve as a suitable substitute for insulin resistance. However, evidence for the relationship between TyG index and risk of diabetes remains limited. This study sought to explore the association of baseline TyG index with risk of developing diabetes in Chinese adults.
This retrospective cohort study was conducted using data from the health screening program in China. A total of 201,298 non-diabetic individuals were included. TyG index was calculated as Ln [fasting plasma glucose (mg/dL) × fasting triglyceride level (mg/dL) / 2]. Diabetes was defined as fasting plasma glucose ≥126 mg/dL and/or self-reported diabetes. Cox proportion-hazard model was employed to evaluate the independent impact of baseline TyG index on future diabetes risk. Sensitivity and subgroup analyses were implemented to verify the reliability of results. Notably, data were downloaded from the DATADRYAD website, and used only for secondary analyses.
During an average follow-up of 3.12 years, among 201,298 individuals aged ≥20 years, 3389 subjects developed diabetes. After adjusting for potential confounders, elevated TyG index were independently correlated with greater risk of incident diabetes (hazard ratio (HR), 3.34; 95% confidence interval (CI), 3.11-3.60). Compared with the lowest quartile (Q1), increasing TyG index (Q2, Q3, and Q4) was related to increased HR estimates of incident diabetes [HR (95% CI), 1.83 (1.49-2.26); 3.29 (2.70-4.01), and 6.26 (5.15-7.60), respectively]. Moreover, a nonlinear relationship was observed between TyG index and risk of diabetes and the slope of the curve increased accompanying the rise of TyG index. Subgroup analysis revealed the positive association was stronger among subjects with age < 40 years, body mass index ≥18.5 kg/m and < 24 kg/m, or systolic blood pressure < 140 mmHg, or in females.
Elevated TyG index is independently correlated with increased risk of incident diabetes in Chinese adults, indicating it may represent a reliable predictor of diabetes in high-risk populations.
最近的研究表明，三酰甘油-葡萄糖指数（TyG 指数）可能是胰岛素抵抗的一个合适替代指标。然而，关于 TyG 指数与糖尿病风险之间的关系的证据仍然有限。本研究旨在探讨中国成年人基线 TyG 指数与发生糖尿病风险之间的关系。
本回顾性队列研究使用了来自中国健康筛查计划的数据。共纳入 201298 例非糖尿病个体。TyG 指数的计算方法为 Ln[空腹血糖（mg/dL）×空腹甘油三酯水平（mg/dL）/2]。糖尿病的定义为空腹血糖≥126mg/dL 和/或自我报告的糖尿病。采用 Cox 比例风险模型评估基线 TyG 指数对未来糖尿病风险的独立影响。进行敏感性和亚组分析以验证结果的可靠性。值得注意的是，数据是从 DATADRYAD 网站下载的，仅用于二次分析。
在平均 3.12 年的随访期间，在 201298 名年龄≥20 岁的个体中，有 3389 例发生了糖尿病。在校正潜在混杂因素后，升高的 TyG 指数与更高的新发糖尿病风险相关（风险比（HR），3.34；95%置信区间（CI），3.11-3.60）。与最低四分位数（Q1）相比，TyG 指数升高（Q2、Q3 和 Q4）与新发糖尿病的 HR 估计值增加相关[HR（95%CI），1.83（1.49-2.26）；3.29（2.70-4.01）和 6.26（5.15-7.60）]。此外，TyG 指数与糖尿病风险之间存在非线性关系，随着 TyG 指数的升高，曲线的斜率增加。亚组分析显示，在年龄<40 岁、体重指数≥18.5kg/m2且<24kg/m2或收缩压<140mmHg或女性中，这种正相关关系更强。
升高的 TyG 指数与中国成年人新发糖尿病风险增加独立相关，表明它可能是高危人群中糖尿病的可靠预测指标。
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