Department of Cardiology, Lishui Hospital, Zhejiang University School of Medicine, Lishui, 323000 Zhejiang, China.
Department of Gastroenterology, Lishui Hospital, Zhejiang University School of Medicine, Lishui, 323000 Zhejiang, China.
Biomed Res Int. 2020 Dec 11;2020:2947067. doi: 10.1155/2020/2947067. eCollection 2020.
Triglyceride-glucose index (TyG index) is associated with type 2 diabetes mellitus (T2DM), but research on this relationship is limited in Japan. The purpose of this study was to evaluate the correlation between TyG index and the risk of T2DM in the Japanese population. Here, 12732 participants were selected from the NAGALA study (NAfld in the Gifu Area, Longitudinal Analysis) conducted between 2004 and 2015 for a retrospective cohort analysis. The association between TyG index and T2DM was assessed using the Cox proportional-hazard model. Subgroup analyses were conducted according to age, sex, smoking status, alcohol consumption, waist circumference, BMI, and follow-up duration. The formula for TyG index was expressed as ln [fasting triglyceride level (mg/dL) × fasting plasma glucose level (mg/dL)/2]. After follow-up, 150 (1.18%) patients developed T2DM. After adjusting for potential confounders, a linear relationship was observed between TyG and the risk of T2DM. After adjusting for age, sex, BMI, waist circumference, HDL-cholesterol, total cholesterol, systolic blood pressure, regular exercise, smoking status, and alcohol consumption, TyG index, as a continuous variable, was associated with an increased risk of T2DM (adjusted hazard ratio (aHR), 1.79; 95% confidence interval (95% CI), 1.25-2.57). Compared with the first quartile of TyG index, subjects in the fourth quartile were 2.33-fold more likely to develop T2DM (aHR 2.33, 95% CI 1.09-4.96; for trend 0.0224). Subgroup analyses showed that the association between TyG index and incident T2DM stably existed in different subgroups according to the variables tested. Therefore, TyG index was linearly related to the risk of incident T2DM in the Japanese population and may be used as a monitoring tool.
甘油三酯-葡萄糖指数（TyG 指数）与 2 型糖尿病（T2DM）相关，但该指标在日本的相关研究有限。本研究旨在评估 TyG 指数与日本人群 T2DM 风险的相关性。在此，我们对 2004 年至 2015 年期间进行的 NAGALA 研究（岐阜地区非酒精性脂肪肝的纵向分析）中的 12732 名参与者进行了回顾性队列分析，从中选择了研究对象。使用 Cox 比例风险模型评估 TyG 指数与 T2DM 的相关性。根据年龄、性别、吸烟状况、饮酒状况、腰围、BMI 和随访时间进行亚组分析。TyG 指数的计算公式为 ln[空腹甘油三酯水平（mg/dL）×空腹血糖水平（mg/dL）/2]。随访后，150 例（1.18%）患者发生 T2DM。在调整潜在混杂因素后，TyG 与 T2DM 风险呈线性关系。在调整年龄、性别、BMI、腰围、高密度脂蛋白胆固醇、总胆固醇、收缩压、有规律的运动、吸烟状况和饮酒状况后，TyG 指数作为连续变量与 T2DM 风险增加相关（调整后的危险比（aHR），1.79；95%置信区间（95%CI），1.25-2.57）。与 TyG 指数第一四分位相比，第四四分位的患者发生 T2DM 的风险增加 2.33 倍（aHR 2.33，95%CI 1.09-4.96；趋势检验 0.0224）。亚组分析显示，根据所测试的变量，TyG 指数与新发 T2DM 之间的关联在不同亚组中均稳定存在。因此，TyG 指数与日本人群新发 T2DM 风险呈线性相关，可作为监测工具。
