Harrison L H
Urology. 1977 Aug;10(2):110-3. doi: 10.1016/0090-4295(77)90006-1.
A randomized prospective study was carried out comparing the recommended dose of amikacin sulfate (Amikin) (15 mg./Kg.) with a lower dose (7.5 mg./Kg.) in the treatment of complicated urinary tract infections. A total of 50 patients were entered in the study over a period of sixteen months. Bacteriologic results were comparable in both groups. Laboratory values remained normal with the exception of 1 patient in the high-dose group who had renal insufficiency. No evidence of ototoxicity was recorded. Our data indicate that low dosage amikacin sulfate is satisfactory in the treatment of complicated urinary tract infections.
进行了一项随机前瞻性研究，比较硫酸阿米卡星（丁胺卡那霉素）的推荐剂量（15毫克/千克）与较低剂量（7.5毫克/千克）治疗复杂性尿路感染的效果。在16个月的时间里，共有50名患者进入该研究。两组的细菌学结果相当。除了高剂量组有1名患者出现肾功能不全外，实验室值均保持正常。未记录到耳毒性的证据。我们的数据表明，低剂量硫酸阿米卡星治疗复杂性尿路感染效果良好。
