Antimicrobial Potential of (PB) Isolated From a Plant Native to the Amazon Against .

The objective of this study was to evaluate the antibacterial action of filamentous bacteria isolated from the leaf. An endophytic bacterium has been identified by classical and molecular techniques as . Screening for antibacterial action against pathogens with medical relevance ( ATCC 700603, ATCC 15692, ATCC 6538, ATCC 27012, , ATCC 24065, and ATCC 24067) demonstrated activity against the bacterium ATCC 0030 with inhibition diameter zones (IDZ) of 17.6 ± 0.25 mm in the preliminary screening in solid medium. After fermentation in liquid medium, an IDZ of 19.6 ± 0.46 mm and a minimum inhibitory concentration (MIC) of 0.5 mg/mL were detected. The antibiofilm action was observed with 100% inhibition of biofilm formation at a concentration of 0.250 mg/mL. When the infection curve was prepared, it was observed that the metabolite was effective in protecting the larvae of . The metabolite does not show toxicity for eukaryotic cells. The leishmanicidal activity demonstrated that the metabolite presented a dose-dependent effect on the promastigotes forms of growth and the estimated IC/72 h was 71.65 ± 7.4 μg/mL. Therefore, it can be concluded that the metabolite produced by the endophytic bacterium sp. is promising for future use as an alternative strategy against bacterial resistance.