来自内生链霉菌 TBRC7642 的抗菌、抗结核、抗疟和细胞毒性物质。
Antibacterial, antitubercular, antimalarial and cytotoxic substances from the endophytic Streptomyces sp. TBRC7642.
机构信息
National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani, 12120, Thailand.
Department of Biology, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand; Antinobacterial research unit, Faculty of Science, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand; Center of Excellence in Applied Biosciences, King Mongkut's Institute of Technology Ladkrabang, Bangkok, 10520, Thailand.
出版信息
Phytochemistry. 2020 Apr;172:112275. doi: 10.1016/j.phytochem.2020.112275. Epub 2020 Jan 24.
Eight previously undescribed naturally-occurring compounds, including abyssomycins Y - Z, methyl aeruginoate, desferri-ferrithocin-4-hydroxyphenethylester, streptomethiocins A - B, furaquinocin I, and streptolactone, along with eleven known compounds were isolated from the endophytic Streptomyces sp. TBRC7642. The chemical structures were determined based on spectroscopic means including 1D, 2D NMR spectroscopy and mass spectrometry. The absolute configurations were assigned by relying on CD spectra and their optical rotations. In addition, the isolated compounds were evaluated for biological activity, such as antimalarial, antitubercular, antibacterial (both Gram-positive and Gram-negative bacteria), as well as for cytotoxicity against MCF-7, NCI-H187, and Vero cells.
从内生链霉菌 TBRC7642 中分离得到 8 种先前未描述的天然存在的化合物，包括深渊霉素 Y-Z、甲基 aeruginoate、去铁-ferrithocin-4-羟基苯乙基酯、streptomethiocins A-B、furaquinocin I 和 streptolactone，以及 11 种已知化合物。根据包括 1D、2D NMR 光谱和质谱在内的光谱方法确定了化学结构。通过 CD 光谱和旋光确定了绝对构型。此外，还评估了分离得到的化合物的生物活性，如抗疟原虫、抗结核、抗菌（革兰氏阳性和革兰氏阴性菌）以及对 MCF-7、NCI-H187 和 Vero 细胞的细胞毒性。
Zotero 插件