Hak Jean-François, Tradi Farouk, Bobot Mickael, Brige Pauline, Habert Paul, Chopinet Sophie, Haffner Aurélie, Soulez Gilles, Guillet Benjamin, Vidal Vincent
Diagnostic and Interventional Radiology Section, Department of Medical Imaging, University Hospital Timone APHM, 278 Rue Saint-Pierre, Marseille 13005, France.
Aix-Marseille University, LIIE, Marseille, France.
Radiol Res Pract. 2020 Oct 23;2020:8831060. doi: 10.1155/2020/8831060. eCollection 2020.
To evaluate the vascular occlusion and midterm tissue toxicity properties of a combination of ethylene-vinyl alcohol (EVOH) (Squid 18®) (75%) and alcohol (25%)-Alco-Squid 18-in a swine model.
Alco-Squid 18 (75% Squid 18® mixed with 25% alcohol) (AS18) was compared to embolization with 96% alcohol alone and to embolization with Squid 18® (S18®) alone. An arteriovenous malformation (AVM) model was created in group 1 ( = 2). Each AVM model was then embolized with AS18 or S18® alone with evaluation of a ratio between the volume of embolic agent divided by the volume of the AVM (evaluated by CT). For group 2 ( = 5), each agent was tested on three different kidneys (upper pole kidney artery). Pre- and postinterventional CTs, angiographies, blood alcohol content dosages, and histological studies (3 months postintervention) were performed.
AS18 has better distal distribution than S18® alone, both in the kidneys (mean capsule-S18® distance: 3.9 mm (±0.23) and mean capsule-AS18 distance: 2.3 mm (±0.11) (=0.029) and in the AVM model. Histological exploration found a higher rate of tubular necrosis with AS18 compared with S18® alone and alcohol alone (3.78 ± 0.44 compared to 2.33 ± 1.22 ( = 0.012) and 1.22 ± 0.67 ( < 0 .0001)). The blood alcohol content was negligible in all cases.
AS18 can suggest a better distal sclerotic and embolic character as compared with S18® alone without systemic toxicity.
在猪模型中评估乙烯 - 乙烯醇共聚物（EVOH）（Squid 18®）（75%）与酒精（25%）的组合——Alco - Squid 18的血管闭塞和中期组织毒性特性。
将Alco - Squid 18（75% Squid 18®与25%酒精混合）（AS18）与单纯使用96%酒精栓塞以及单纯使用Squid 18®（S18®）栓塞进行比较。在第1组（n = 2）中创建动静脉畸形（AVM）模型。然后用AS18或S18®单独栓塞每个AVM模型，并通过计算栓塞剂体积与AVM体积之比（通过CT评估）进行评估。对于第2组（n = 5），每种制剂在三个不同的肾脏（上极肾动脉）上进行测试。进行介入前和介入后的CT、血管造影、血醇含量测定以及组织学研究（介入后3个月）。
在肾脏（平均包膜 - S18®距离：3.9 mm（±0.23），平均包膜 - AS18距离：2.3 mm（±0.11）（P = 0.029））和AVM模型中，AS18的远端分布均优于单独的S18®。组织学检查发现，与单独使用S18®和单独使用酒精相比，AS18导致的肾小管坏死率更高（分别为3.78 ± 0.44、2.33 ± 1.22（P = 0.012）和1.22 ± 0.67（P < 0.0001））。所有情况下血醇含量均可忽略不计。
与单独的S18®相比，AS18具有更好的远端硬化和栓塞特性，且无全身毒性。
