Sakata S, Nagai K, Imai T, Komaki T, Miura K
Third Department of Internal Medicine, Gifu University School of Medicine, Japan.
J Endocrinol Invest. 1987 Aug;10(4):407-11. doi: 10.1007/BF03348158.
A case of diabetes mellitus who had high levels of fasting immunoreactive insulin (IRI) and low levels of immunoreactive C-peptide (CPR) is reported. Examination of her serum disclosed the presence of IgG class k + lambda type anti-insulin autoantibodies. She has never been treated with insulin, nor had drugs which have been reported to be responsible for inducing insulin autoimmune syndrome. Despite the presence of autoantibodies against insulin, she has never experienced hypoglycemia. Significance of the production of autoantibodies against insulin and physicochemical parameters of anti-insulin antibodies in her serum are discussed.
报告了一例空腹免疫反应性胰岛素（IRI）水平高而免疫反应性C肽（CPR）水平低的糖尿病患者。对其血清检测发现存在IgG类κ+λ型抗胰岛素自身抗体。她从未接受过胰岛素治疗，也未使用过据报道可诱发胰岛素自身免疫综合征的药物。尽管存在抗胰岛素自身抗体，但她从未发生过低血糖。本文讨论了抗胰岛素自身抗体产生的意义以及她血清中抗胰岛素抗体的理化参数。
