Dietetics and Nutrition Department, Ng Teng Fong General Hospital, Singapore.
Ann Acad Med Singap. 2020 Aug;49(8):573-581.
Number of recently published studies on nutritional support in the intensive care unit (ICU) have resulted in a paradigm shift of clinical practices. This review summarises the latest evidence in four main topics in the ICU, namely: (1) function of validated nutrition screening/assessment tools, (2) types and validity of body composition measurements, (3) optimal energy and protein goals, and (4) delivery methods.
Recent studies that investigated the above aims were outlined and discussed. In addition, recent guidelines were also compared to highlight the similarities and differences in their approach to the nutrition support of critically ill patients.
Regardless of nutritional status and body composition, all patients with >48 hours of ICU stay are at nutrition risk and should receive individualised nutrition support. Although a recent trial did not demonstrate an advantage of indirect calorimetry over predictive equations, it was recommended that indirect calorimetry be used to set energy targets with better accuracy. Initiation of enteral nutrition (EN) within 24-48 hours was shown to be associated with improved clinical outcomes. The energy and protein goals should be achieved gradually over the first week of ICU stay. This practice should be protocolised and regularly audited as critically ill patients receive only part of their energy and protein goals.
Metabolic demands of critically ill patients can be variable and nutrition support should be tailored to each patient. Given that many nutrition studies are on-going, we anticipate improvements in the individualisation of nutrition support in the near future.
最近发表的许多关于重症监护病房(ICU)营养支持的研究导致了临床实践的范式转变。这篇综述总结了 ICU 中四个主要主题的最新证据,即:(1)经过验证的营养筛查/评估工具的功能,(2)身体成分测量的类型和有效性,(3)最佳能量和蛋白质目标,以及(4)输送方法。
概述和讨论了最近研究这些目标的研究。此外,还比较了最近的指南,以突出它们在为危重病患者提供营养支持方面的相似点和不同点。
无论营养状况和身体成分如何,所有 ICU 住院时间超过 48 小时的患者都存在营养风险,应接受个体化营养支持。尽管最近的一项试验并未显示间接热量法优于预测方程,但建议使用间接热量法更准确地设定能量目标。在 24-48 小时内开始肠内营养(EN)与改善临床结果相关。在 ICU 入住的第一周内,能量和蛋白质目标应逐渐达到。应制定方案并定期审核,因为危重病患者仅能达到其部分能量和蛋白质目标。
危重病患者的代谢需求可能不同,营养支持应根据每个患者进行调整。鉴于许多营养研究正在进行中,我们预计在不久的将来会改善营养支持的个体化。