Takagi T
Department of Orthopaedic Surgery, Yokohama City University School of Medicine, Kanagawa, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1987 Jun;61(6):775-83.
Rabbits immunized with heat-killed Escherichia coli 0:14 for 8-10 months developed lymphocyte infiltration in the synovium at a significantly (p less than 0.05) higher rate (61.1%, 22 of 36 knees) than animals immunized for 4 months (31.3%, 10 of 32). Serum rheumatoid factor-like substance (RFLS) was positive (RAHA-titer more than 80) as early as 3 weeks after the initial treatment. After 15 weeks of immunization 90.9% (20 of 22 rabbits) of the animals were RFLS positive. Lymphocyte infiltration in the synovium of knees was observed more frequently (81.8%, 9 of 11 rabbits) (p less than 0.05) in the group with positive RFLS earlier than 8 weeks following immunization than in that with RFLS only after this period (18.2%, 2 of 11). These observations suggest that the long viability of serum RFLS and certain factors inducing early RFLS synthesis might be important in producing arthritis in rabbit immunized with E. coli.
用热灭活的大肠杆菌O:14免疫8 - 10个月的兔子，滑膜中淋巴细胞浸润的发生率（61.1%，36个膝关节中有22个）显著高于（p < 0.05）免疫4个月的动物（31.3%，32个膝关节中有10个）。血清类风湿因子样物质（RFLS）在初次治疗后3周就呈阳性（类风湿关节炎血凝试验滴度超过80）。免疫15周后，90.9%（22只兔子中有20只）的动物RFLS呈阳性。免疫8周前RFLS呈阳性的组中，膝关节滑膜淋巴细胞浸润的发生率（81.8%，11只兔子中有9只）比仅在此之后RFLS呈阳性的组更频繁（18.2%，11只兔子中有2只）（p < 0.05）。这些观察结果表明，血清RFLS的长期存在以及某些诱导早期RFLS合成的因素可能在用大肠杆菌免疫的兔子发生关节炎过程中起重要作用。
