实验性变应性脑脊髓炎向骨髓嵌合体的转移。内皮细胞不是限制因素。
Transfer of experimental allergic encephalomyelitis to bone marrow chimeras. Endothelial cells are not a restricting element.
作者信息
Hinrichs D J, Wegmann K W, Dietsch G N
机构信息
Veterans Administration Medical Center, Portland, Oregon 97207.
出版信息
J Exp Med. 1987 Dec 1;166(6):1906-11. doi: 10.1084/jem.166.6.1906.
Abstract
The adoptive transfer of clinical and histopathologic signs of experimental allergic encephalomyelitis (EAE) requires MHC compatibility between cell donor and cell recipient. The results of adoptive transfer studies using F1 to parent bone marrow chimeras as recipients of parental-derived BP-sensitive spleen cells indicate that this restriction is not expressed at the level of the endothelial cell but is confined to the cells of bone marrow derivation. Furthermore, these results indicate that the development of EAE is not dependent on the activity of MHC-restricted cytotoxic cells.
摘要
实验性变应性脑脊髓炎（EAE）临床和组织病理学体征的过继转移需要细胞供体与细胞受体之间的MHC相容性。以F1代至亲代骨髓嵌合体作为亲代来源的对BP敏感的脾细胞受体进行过继转移研究的结果表明，这种限制并非在内皮细胞水平表现出来，而是局限于骨髓来源的细胞。此外，这些结果表明EAE的发展并不依赖于MHC限制性细胞毒性细胞的活性。
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