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实验性变应性脑脊髓炎向骨髓嵌合体的转移。内皮细胞不是限制因素。

Transfer of experimental allergic encephalomyelitis to bone marrow chimeras. Endothelial cells are not a restricting element.

作者信息

Hinrichs D J, Wegmann K W, Dietsch G N

机构信息

Veterans Administration Medical Center, Portland, Oregon 97207.

出版信息

J Exp Med. 1987 Dec 1;166(6):1906-11. doi: 10.1084/jem.166.6.1906.

DOI:10.1084/jem.166.6.1906
PMID:3316476
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2188803/
Abstract

The adoptive transfer of clinical and histopathologic signs of experimental allergic encephalomyelitis (EAE) requires MHC compatibility between cell donor and cell recipient. The results of adoptive transfer studies using F1 to parent bone marrow chimeras as recipients of parental-derived BP-sensitive spleen cells indicate that this restriction is not expressed at the level of the endothelial cell but is confined to the cells of bone marrow derivation. Furthermore, these results indicate that the development of EAE is not dependent on the activity of MHC-restricted cytotoxic cells.

摘要

实验性变应性脑脊髓炎（EAE）临床和组织病理学体征的过继转移需要细胞供体与细胞受体之间的MHC相容性。以F1代至亲代骨髓嵌合体作为亲代来源的对BP敏感的脾细胞受体进行过继转移研究的结果表明，这种限制并非在内皮细胞水平表现出来，而是局限于骨髓来源的细胞。此外，这些结果表明EAE的发展并不依赖于MHC限制性细胞毒性细胞的活性。

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J Exp Med. 1987 Dec 1;166(6):1906-11. doi: 10.1084/jem.166.6.1906.
2
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本文引用的文献

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Vascular endothelium as a major participant in T-lymphocyte immunity.血管内皮作为T淋巴细胞免疫的主要参与者。
Cell Immunol. 1982 Jul 1;70(2):357-61. doi: 10.1016/0008-8749(82)90336-7.
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Acute experimental autoimmune encephalomyelitis in mice. I. Adjuvant action of Bordetella pertussis is due to vasoactive amine sensitization and increased vascular permeability of the central nervous system.小鼠急性实验性自身免疫性脑脊髓炎。I. 百日咳博德特氏菌的佐剂作用归因于血管活性胺致敏和中枢神经系统血管通透性增加。
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The immunopathology of experimental allergic encephalomyelitis. II. Endothelial cell Ia increases prior to inflammatory cell infiltration.实验性变应性脑脊髓炎的免疫病理学。II. 炎症细胞浸润之前内皮细胞Ia增加。
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Recipient contributions to serial passive transfer of experimental allergic encephalomyelitis.受体对实验性变应性脑脊髓炎系列被动转移的贡献。
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Modification of the clinical and histopathologic expression of experimental allergic encephalomyelitis by the vasoactive amine antagonist cyproheptadine.血管活性胺拮抗剂赛庚啶对实验性变应性脑脊髓炎临床及组织病理学表现的影响
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Different mechanisms of release of vasoactive amines by mast cells occur in T cell-dependent compared to IgE-dependent cutaneous hypersensitivity responses.与IgE依赖的皮肤超敏反应相比，在T细胞依赖的皮肤超敏反应中，肥大细胞释放血管活性胺的机制不同。
Eur J Immunol. 1984 Jan;14(1):40-7. doi: 10.1002/eji.1830140108.
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T cells produce an antigen-binding factor with in vivo activity analogous to IgE antibody.T细胞产生一种在体内具有类似于IgE抗体活性的抗原结合因子。
J Exp Med. 1983 Mar 1;157(3):862-73. doi: 10.1084/jem.157.3.862.
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Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species.从几种哺乳动物的中枢神经组织中大规模制备髓鞘碱性蛋白。
Prep Biochem. 1972;2(2):139-65. doi: 10.1080/00327487208061467.
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On the presence of Ia-positive endothelial cells and astrocytes in multiple sclerosis lesions and its relevance to antigen presentation.多发性硬化症病灶中Ia阳性内皮细胞和星形胶质细胞的存在及其与抗原呈递的相关性。
J Neuroimmunol. 1985 Apr;8(1):1-14. doi: 10.1016/s0165-5728(85)80043-6.
10
Prazosin treatment suppresses increased vascular permeability in both acute and passively transferred experimental autoimmune encephalomyelitis in the Lewis rat.哌唑嗪治疗可抑制Lewis大鼠急性和被动转移实验性自身免疫性脑脊髓炎中血管通透性的增加。
J Immunol. 1986 Dec 1;137(11):3444-50.