The Hormel Institute, University of Minnesota, Austin, MN, USA.
The Hormel Institute, University of Minnesota, Austin, MN, USA; Department of Obstetrics and Gyneacology, Hurley Medical Center, Flint, MI, USA.
Pharmacol Ther. 2021 Apr;220:107717. doi: 10.1016/j.pharmthera.2020.107717. Epub 2020 Oct 24.
Programmed cell death (PCD) has been a major area of constantly growing interest over the last three decades. Originally, apoptosis was considered the only mechanistic pathway for PCD, but recently several different pathways (i.e., necroptosis, pyroptosis, ferroptosis) have emerged as important in both normal and pathological conditions. This review focuses on programmed cell necrosis (i.e., necroptosis) as a promising research direction that will help us in understanding the molecular and cellular processes behind different pathological conditions, such as chronic inflammation, neurodegeneration, and cardiovascular diseases. In addition, we discuss natural and chemical compounds and novel targeted therapies triggering necroptosis to induce cell death in cancer cells to overcome chemoresistance.
程序性细胞死亡（PCD）是过去三十年来人们持续关注的一个重要领域。最初，细胞凋亡被认为是 PCD 的唯一机制途径，但最近几种不同的途径（即坏死性凋亡、细胞焦亡、铁死亡）已被证明在正常和病理条件下都很重要。本综述重点介绍程序性细胞坏死（即坏死性凋亡）作为一个有前途的研究方向，它将帮助我们理解不同病理条件（如慢性炎症、神经退行性疾病和心血管疾病）背后的分子和细胞过程。此外，我们还讨论了触发坏死性凋亡以诱导癌细胞死亡从而克服化疗耐药性的天然和化学化合物以及新型靶向治疗。
