Bishop W R, Kawashima Y, Bell R M
Department of Biochemistry, Duke University Medical Center, Durham, North Carolina.
J Neural Transm Suppl. 1987;24:229-37.
Assembly of the phospholipid bilayer of cellular membranes is a fundamental aspect of cell growth and proliferation. Phospholipids are concomitantly synthesized and inserted at the cytoplasmic surface of the endoplasmic reticulum. Following this asymmetric assembly, transmembrane movement to the lumenal leaflet of the endoplasmic reticulum must occur in order to ensure coordinated growth of the bilayer. For phosphatidylcholine, the predominant phospholipid of eukaryotic membranes, this latter process appears to be facilitated by a specific transport protein.
细胞膜磷脂双层的组装是细胞生长和增殖的一个基本方面。磷脂在内质网的细胞质表面同时合成并插入。在这种不对称组装之后，必须发生跨膜移动至内质网的腔面膜层，以确保双层膜的协调生长。对于真核细胞膜中占主导地位的磷脂磷脂酰胆碱来说，后一过程似乎由一种特定的转运蛋白促进。
