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CORR Insights®: Is Use of BMP-2 Associated with Tumor Growth and Osteoblastic Differentiation in Murine Models of Osteosarcoma?CORR 见解®：在骨肉瘤小鼠模型中，骨形态发生蛋白-2（BMP-2）的使用与肿瘤生长和成骨细胞分化有关吗？
Clin Orthop Relat Res. 2020 Dec;478(12):2934-2935. doi: 10.1097/CORR.0000000000001546.
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Clin Orthop Relat Res. 2020 Dec;478(12):2921-2933. doi: 10.1097/CORR.0000000000001422.
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Bone morphogenetic protein-2 promotes osteosarcoma growth by promoting epithelial-mesenchymal transition (EMT) through the Wnt/β-catenin signaling pathway.骨形态发生蛋白-2 通过 Wnt/β-连环蛋白信号通路促进上皮-间充质转化（EMT）促进骨肉瘤生长。
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Focal adhesion kinase activity is required for bone morphogenetic protein--Smad1 signaling and osteoblastic differentiation in murine MC3T3-E1 cells.粘着斑激酶活性是小鼠MC3T3-E1细胞中骨形态发生蛋白-Smad1信号传导和成骨细胞分化所必需的。
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本文引用的文献

1
Is Use of BMP-2 Associated with Tumor Growth and Osteoblastic Differentiation in Murine Models of Osteosarcoma?骨形态发生蛋白-2（BMP-2）的使用是否与骨肉瘤小鼠模型中的肿瘤生长和成骨分化有关？
Clin Orthop Relat Res. 2020 Dec;478(12):2921-2933. doi: 10.1097/CORR.0000000000001422.
2
Identification of co-expression modules and pathways correlated with osteosarcoma and its metastasis.鉴定与骨肉瘤及其转移相关的共表达模块和途径。
World J Surg Oncol. 2019 Mar 8;17(1):46. doi: 10.1186/s12957-019-1587-7.
3
Bone morphogenetic protein-2 promotes osteosarcoma growth by promoting epithelial-mesenchymal transition (EMT) through the Wnt/β-catenin signaling pathway.骨形态发生蛋白-2 通过 Wnt/β-连环蛋白信号通路促进上皮-间充质转化（EMT）促进骨肉瘤生长。
J Orthop Res. 2019 Jul;37(7):1638-1648. doi: 10.1002/jor.24244. Epub 2019 Mar 28.
4
Clinical, Pathological, and Ethical Considerations for the Conduct of Clinical Trials in Dogs with Naturally Occurring Cancer: A Comparative Approach to Accelerate Translational Drug Development.对患有自然发生癌症的犬类进行临床试验的临床、病理和伦理考量：加速转化药物开发的比较方法
ILAR J. 2018 Dec 1;59(1):99-110. doi: 10.1093/ilar/ily019.
5
Canine sarcomas as a surrogate for the human disease.犬肉瘤可作为人类疾病的替代物。
Pharmacol Ther. 2018 Aug;188:80-96. doi: 10.1016/j.pharmthera.2018.01.012. Epub 2018 Mar 9.
6
"To B(MP-2) or Not To B(MP-2)" or "Much Ado About Nothing": Are Orthobiologics in Tumor Surgery Worth the Risks?“是用（MP-2）还是不用（MP-2）”还是“无事生非”：肿瘤外科中的矫形生物制剂是否值得冒险？
Clin Cancer Res. 2015 Jul 1;21(13):2889-91. doi: 10.1158/1078-0432.CCR-14-3069. Epub 2015 Jan 21.
7
Development of a Model System to Evaluate Local Recurrence in Osteosarcoma and Assessment of the Effects of Bone Morphogenetic Protein-2.建立一个用于评估骨肉瘤局部复发的模型系统并评估骨形态发生蛋白-2 的效果。
Clin Cancer Res. 2015 Jul 1;21(13):3003-12. doi: 10.1158/1078-0432.CCR-14-0986. Epub 2014 Dec 3.
8
Increased invasiveness of osteosarcoma mesenchymal stem cells induced by bone-morphogenetic protein-2.骨形态发生蛋白-2 诱导骨肉瘤间充质干细胞侵袭力增强。
In Vitro Cell Dev Biol Anim. 2013 Apr;49(4):270-8. doi: 10.1007/s11626-013-9598-0. Epub 2013 Mar 22.
9
Whole genome sequencing.全基因组测序
Methods Mol Biol. 2010;628:215-26. doi: 10.1007/978-1-60327-367-1_12.
10
Mesenchymal stem cell-mediated gene delivery of bone morphogenetic protein-2 in an articular fracture model.间充质干细胞介导的骨形态发生蛋白-2在关节骨折模型中的基因递送
Mol Ther. 2007 Aug;15(8):1543-50. doi: 10.1038/sj.mt.6300192. Epub 2007 May 22.

CORR Insights®: Is Use of BMP-2 Associated with Tumor Growth and Osteoblastic Differentiation in Murine Models of Osteosarcoma?

作者信息

Zachos Terri A

机构信息

T. A. Zachos, Department of Orthopaedic Surgery, University of California Davis Health System, Sacramento, CA, USA.

出版信息

Clin Orthop Relat Res. 2020 Dec;478(12):2934-2935. doi: 10.1097/CORR.0000000000001546.

DOI:10.1097/CORR.0000000000001546
PMID:33165052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7899422/
Abstract
摘要