Barrow Neurological Institute, Dignity Health St. Joseph's Hospital and Medical Center, Phoenix, Arizona, U.S.A.; and.
BioMag Laboratory, HUS Medical Imaging Center, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.
J Clin Neurophysiol. 2020 Nov;37(6):574-584. doi: 10.1097/WNP.0000000000000518.
Auditory evoked fields (AEFs) are well suited for studies of auditory processing in patients. Their sources have been localized to Heschl's gyri and to the supratemporal auditory cortices. Auditory evoked fields are known to be modulated by peripheral and central lesions of auditory pathways and to reflect group-level pathophysiology of neurodevelopmental and psychiatric disorders. They are useful in lateralization of language processes for planning neurosurgery and for localization of language-related cortex. The recently developed artifact rejection and movement compensation methods will enhance and extend the use of AEFs in studies of clinical patients and pediatric groups. New pediatric magnetoencephalography systems will facilitate clinical AEF studies of developmental disorders. In addition to their established use in planning neurosurgery, AEF findings in several new clinical patient groups suffering, e.g., from developmental, neurodegenerative, or psychiatric disorders have been reported. Several recent investigations report the correlations with clinical symptoms and sensitivity and specificity profiles of AEFs in studies of these disorders; this development is mandatory in gaining wider clinical approval for the use of AEFs in clinical practice dealing with individual patients. Most promising future research lines of clinical applicability of AEFs focus on developmental and psychiatric disorders.
听觉诱发电位（AEF）非常适合用于研究患者的听觉处理。它们的源已被定位到 Heschl 回和颞上听觉皮层。已知听觉诱发电位可被听觉通路的外周和中枢病变调制，并反映神经发育和精神障碍的组水平病理生理学。它们在计划神经外科手术的语言过程的侧化以及语言相关皮层的定位方面非常有用。最近开发的伪迹拒绝和运动补偿方法将增强和扩展 AEF 在临床患者和儿科群体研究中的应用。新的儿科脑磁图系统将方便对发育障碍进行临床 AEF 研究。除了在计划神经外科手术中的既定用途外，还报道了在患有发育障碍、神经退行性或精神障碍等新的临床患者群体中，AEF 的发现；在这些疾病的研究中，AEF 的临床症状相关性、敏感性和特异性特征的研究发展是获得更广泛的临床认可的必要条件，这对于将 AEF 应用于针对个体患者的临床实践是强制性的。AEF 临床应用最有前途的未来研究方向集中在发育和精神障碍上。
